Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Caution is advised when interpreting subgroup analyses

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Nettis MA, Lombardo G, Hastings C, Zajkowska Z, Mariani N, Nikkheslat N, et al. Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial. Neuropsychopharmacology. 2021;46:939–48.

  2. 2.

    Sun X, Briel M, Walter SD, Guyatt GH. Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses. BMJ 2010;340:c117.

    Article  Google Scholar 

  3. 3.

    Sun X, Briel M, Busse JW, You JJ, Akl EA, Mejza F, et al. Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ 2012;344:e1553.

    Article  Google Scholar 

  4. 4.

    Rothwell PM. Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation. Lancet. 2005;365:176–86.

    Article  Google Scholar 

  5. 5.

    Brookes ST, Whitley E, Peters TJ, Mulheran PA, Egger M, Davey, et al. Subgroup analyses in randomised controlled trials: quantifying the risks of false-positives and false-negatives. Health Technol Assess. 2001;5:1–56.

    CAS  Article  Google Scholar 

  6. 6.

    Oxman AD. Subgroup analyses. BMJ 2012;344:e2022.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Contributions

KM: Conceptualization, Methodology, Writing – Original Draft. ASPM: Methodology, Writing – Review & Editing.

Corresponding author

Correspondence to Klaus Munkholm.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Munkholm, K., Paludan-Müller, A.S. Caution is advised when interpreting subgroup analyses. Neuropsychopharmacol. (2021). https://doi.org/10.1038/s41386-021-01025-2

Download citation

Search

Quick links