Unraveling oxytocin’s peripheral vs. central mechanisms


Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    United Nations Office on Drugs and Crime. World Drug Report. June 2017.

  2. 2.

    Leong KC, Cox SS, King C, Becker H, Reichel CM. Oxytocin and rodent models of addiction. Int Rev Neurobiol. 2018;40:201–47.

    Article  Google Scholar 

  3. 3.

    Nishimori K, Takayanagi Y, Yoshida M, Kasahara Y, Young LJ, Kawamata M. New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behavior and control of energy balance. Prog Brain Res. 2008;170:79–90.

    CAS  Article  Google Scholar 

  4. 4.

    Ermisch A, Barth T, Ruhle HJ, Skopkova J, Hrbas P, Landgraf R. On the blood-brain barrier to peptides: an accumulation of labelled vasopressin, DesGlyNH2-vasopressin and oxytocin by brain regions. Endocrinologia Experimentalis. 1985;19:29–37.

    CAS  PubMed  Google Scholar 

  5. 5.

    Lee MR, Shnitko TA, Blue SW, Kaucher AV, Winchell AJ, Erikson DW, et al. Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. Nat Commun. 2020;11:2783.

    CAS  Article  Google Scholar 

  6. 6.

    Carter DA, Lightman SL. A role for the area postrema in mediating cholecystokinin-stimulated oxytocin secretion. Brain Res. 1987;435:327–30.

    CAS  Article  Google Scholar 

  7. 7.

    Hosoi T, Okuma Y, Matsuda T, Nomura Y. Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion. Auton Neurosci. 2005;120:104–7.

    CAS  Article  Google Scholar 

  8. 8.

    Gao X, Phillips PA, Widdop RE, Trinder D, Jarrott B, Johnson CI. Presence of functional vasopressin V1 receptors in rat vagal afferent neurons. Neurosci Lett. 1992;145:79–82.

    CAS  Article  Google Scholar 

  9. 9.

    Becker JB, McClellan ML, Reed BG. Sex differences, gender and addiction. J Neurosci Res. 2017;95:136–47.

    CAS  Article  Google Scholar 

Download references


I would like to thank Jordan Carter and Yavin Shaham for comments on the original version of this paper.

Author information



Corresponding author

Correspondence to Carmela M. Reichel.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Reichel, C.M. Unraveling oxytocin’s peripheral vs. central mechanisms. Neuropsychopharmacol. (2020). https://doi.org/10.1038/s41386-020-0742-8

Download citation