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Rate matters: rapid cocaine delivery promotes incubation of cocaine craving

Neuropsychopharmacology (2018) | Download Citation

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References

  1. 1.

    O’Brien CP, Childress AR, McLellan AT, Ehrman R. Classical conditioning in drug-dependent humans. Ann N Y Acad Sci. 1992;654:400–15.

  2. 2.

    Li X, Venniro M, Shaham Y. Translational research on incubation of cocaine craving. JAMA Psychiatry. 2016;73:1115–6. https://doi.org/10.1001/jamapsychiatry.2016.2110

  3. 3.

    Allain F, Minogianis EA, Roberts DC, Samaha AN. How fast and how often: the pharmacokinetics of drug use are decisive in addiction. Neurosci Biobehav Rev. 2015;56:166–79. https://doi.org/10.1016/j.neubiorev.2015.06.012

  4. 4.

    Gawin FH, Ellinwood EH Jr.. Cocaine and other stimulants. Actions, Abus, Treat N Engl J Med. 1988;318:1173–82. https://doi.org/10.1056/NEJM198805053181806

  5. 5.

    Wakabayashi KT, Weiss MJ, Pickup KN, Robinson TE. Rats markedly escalate their intake and show a persistent susceptibility to reinstatement only when cocaine is injected rapidly. J Neurosci. 2010;30:11346–55. https://doi.org/10.1523/JNEUROSCI.2524-10.2010

  6. 6.

    Gueye AB, Allain F, Samaha AN. Intermittent intake of rapid cocaine injections promotes the risk of relapse and increases mesocorticolimbic BDNF levels during abstinence. Neuropsychopharmacology 2018. https://doi.org/10.1038/s41386-018-0249-8

  7. 7.

    Kawa AB, Bentzley BS, Robinson TE. Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior. Psychopharmacology. 2016;233:3587–602. https://doi.org/10.1007/s00213-016-4393-8

  8. 8.

    Nicolas C, Russell T, Pierce A, Holley A, You Z, McCarthy M, et al. Sex differences in the potentiation of intermittent self-administration on incubation of cocaine craving: effect of estrous cycle. Soc Neurosci Abstr. 2018: 603.01

  9. 9.

    Li X, Wolf ME. Multiple faces of BDNF in cocaine addiction. Behav Brain Res. 2015;279:240–54. https://doi.org/10.1016/j.bbr.2014.11.018

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Acknowledgements

We thank Dr. Yavin Shaham for insightful comments on the draft of this manuscript.

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Affiliations

  1. Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA

    • Ida Fredriksson
  2. Department of Psychology, University of Maryland College Park, College Park, MD, USA

    • Xuan Li

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Correspondence to Xuan Li.

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https://doi.org/10.1038/s41386-018-0275-6