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Sex differences in schizophrenia: estrogen and mitochondria

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References

  1. 1.

    Gogos A, Sbisa AM, Sun J, Gibbons A, Udawela M, Dean B. A role for estrogen in schizophrenia: clinical and preclinical findings. Int J Endocrinol. 2015;2015:615356.

  2. 2.

    Liao TL, Tzeng CR, Yu CL, Wang YP, Kao SH. Estrogen receptor beta in mitochondria: implications for mitochondrial bioenergetics and tumorigenesis. Ann N Y Acad Sci. 2015;1350:52–60.

  3. 3.

    Cuperfain AB, Zhang ZL, Kennedy JL, Gonçalves VF. The complex interaction of mitochondrial genetics and mitochondrial pathways in psychiatric disease. Mol Neuropsychiatry. 2018;4(1):52–69.

  4. 4.

    Verge B, Alonso Y, Valero J, Miralles C, Vilella E, Martorell L. Mitochondrial DNA (mtDNA) and schizophrenia. Eur Psychiatry. 2011;26(1):45–56.

  5. 5.

    Ventura-Clapier R, Moulin M, Piquereau J, Lemaire C, Mericskay M, Veksler V, et al. Mitochondria: a central target for sex differences in pathologies. Clin Sci. 2017;131(9):803–22.

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Acknowledgments

We would like to acknowledge the Judy and Larry Tanenbaum Family Foundation for their support to this study.

Funding

J.L.K. has been funded by Genome Canada, The Ontario Ministry of Research and Innovation, CIHR, a BBRF/NARSAD Distinguished Investigator Award, and the Judy and Larry Tanenbaum Foundation. J.L.K. has also received speaker honoraria and expenses from Eli Lilly, Novartis, and Shire, and consultant honoraria and expenses from Roche, and is a nonpaid member of the SAB of Assurex Health Inc.

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Competing interests

The authors declare no competing interest.

Correspondence to James L. Kennedy.

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DOI

https://doi.org/10.1038/s41386-018-0228-0