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An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders

Neuropsychopharmacologyvolume 44pages235236 (2019) | Download Citation

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  1. 1.

    Rasgon NL, McEwen BS. Insulin resistance-a missing link no more. Mol Psychiatry. 2016;21:1648–52.

  2. 2.

    Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, et al. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proceedings of the National Academy of Sciences. 2018;115:8627–32.

  3. 3.

    Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc Natl Acad Sci USA. 2013;110:4804–9.

  4. 4.

    Bigio B, Mathe AA, Sousa VC, Zelli D, Svenningsson P, McEwen BS, et al. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proc Natl Acad Sci USA. 2016;113:7906–11.

  5. 5.

    Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, et al. Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress. Neuron. 2017;96:402–13. e405

  6. 6.

    Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, et al. Treatment resistant depression: a multi-scale, systems biology approach. Neurosci Biobehav Rev. 2017;84:272–88.

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Authors acknowledge funding support from the American Foundation for Suicide Prevention (AFSP), the Robertson Foundation and the Hope for Depression Research Foundation (HDRF) (to C.N. and B.S.M.).

Author information


  1. Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, USA

    • Carla Nasca
    • , Natalie Rasgon
    •  & Bruce McEwen
  2. Center for Neuroscience in Women’s Health, Stanford University, Palo Alto, CA, 91304, USA

    • Natalie Rasgon


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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Carla Nasca or Bruce McEwen.

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