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Guidance cues: linking drug use in adolescence with psychiatric disorders

Neuropsychopharmacologyvolume 44pages225226 (2019) | Download Citation

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  1. 1.

    Gulley JM, Juraska JM (2013). The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. Neuroscience

  2. 2.

    Reynolds LM, Pokinko M, Torres-Berrío A, Cuesta S, Lambert LC, Del Cid-Pellitero E, et al. DCC receptors drive prefrontal cortex maturation by determining dopamine axon targeting in adolescence. Biol Psychiatry. 2018a;83:181–92.

  3. 3.

    Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, et al. Non-contingent exposure to amphetamine in adolescence recruits miR-218 to regulate Dcc expression in the VTA. Neuropsychopharmacology. 2018;43:900–11.

  4. 4.

    Reynolds LM, Makowski CS, Yogendran SV, Kiessling S, Cermakian N, Flores C. Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner. Neuropsychopharmacology. 2015;40:1101–12.

  5. 5.

    Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, et al. (2018b) Early adolescence is a critical period for the maturation of inhibitory behavior. In Press, Cerebral Cortex

  6. 6.

    Vosberg DE, Zhang Y, Menegaux A, Chalupa A, Manitt C, Zehntner S, et al. Mesocorticolimbic connectivity and volumetric alterations in DCC mutation carriers. J Neurosci. 2018;38:4655–4665.

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This work was supported by the National Institute on Drug Abuse (R01DA037911 to C.F.; F31DA041188 to L.M.R.), the Canadian Institutes of Health Research (MOP-74709 to C.F.), and the Natural Sciences and Engineering Research Council of Canada (2982226 to C.F.). C.F. is a research scholar of the Fonds de Recherche du Québec - Santé. L.M.R. was supported by predoctoral fellowships from The Djavad Mowafaghian Foundation and Fulbright Canada.

Author information


  1. Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada

    • Lauren M. Reynolds
  2. Department of Psychiatry and Department of Neurology and Neurosurgery, McGill University, Douglas Mental Health University Institute, Montréal, QC, Canada

    • Lauren M. Reynolds
    •  & Cecilia Flores


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The authors declare that they have no competing interests.

Corresponding author

Correspondence to Cecilia Flores.

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