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Dynamic network targeting for closed-loop deep brain stimulation

Neuropsychopharmacologyvolume 44pages219220 (2019) | Download Citation

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  1. 1.

    Widge AS, Malone DA Jr., Dougherty DD. Closing the loop on deep brain stimulation for treatment-resistant depression. Front Neurosci. 2018;12:640–10.

  2. 2.

    Riva-Posse P, Choi KS, Holtzheimer PE, Crowell AL, Garlow SJ, Rajendra JK, et al. A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression. Mol Psychiatry. 2017;23:1–7.

  3. 3.

    Meidahl AC, Tinkhauser G, Herz DM, Cagnan H, Debarros J, Brown P. Adaptive deep brain stimulation for movement disorders: the long road to clinical therapy. Mov Disord. 2017;32:810–9.

  4. 4.

    Molina R, Okun MS, Shute JB, Opri E, Rossi PJ, Martinez-Ramirez D, et al. Report of a patient undergoing chronic responsive deep brain stimulation for Tourette syndrome: proof of concept. J Neurosurg. 2017 1–7

  5. 5.

    Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, et al. Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nat Commun. 2018;9:1–8.

  6. 6.

    Widge AS, Ellard KK, Paulk AC, Basu I, Yousefi A, Zorowitz S, et al. Treating refractory mental illness with closed-loop brain stimulation: progress towards a patient-specific transdiagnostic approach. Exp Neurol. 2017;287:361–72.

  7. 7.

    Vinogradov S, Herman A. Psychiatric illnesses as oscillatory connectomopathies. Neuropsychopharmacology. 2016;41:387–8.

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A.S.W. acknowledges support from the OneMind Institute, National Institutes of Health (contracts MH10972, MH111320, NS100548, and MH113103), MnDRIVE Brain Conditions initiative, and MnDRIVE Medical Discovery Team on Addictions. A.B.H. acknowledges support from the MnDRIVE Brain Conditions initiative.

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  1. Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA

    • Alexander B. Herman
    •  & Alik S. Widge


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The authors declare no competing interests.

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Correspondence to Alik S. Widge.

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