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Vaccines to treat opioid use disorders and to reduce opioid overdoses

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  1. 1.

    Bremer PT, Kimishima A, Schlosburg JE, Zhou B, Collins KC, Janda KD. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs. Angew Chem Int Ed Engl. 2016;55:3772–5.

  2. 2.

    Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, et al. Opioid dose- and route-dependent efficacy of oxycodone and heroin vaccines in rats. J Pharmacol Exp Ther. 2018;365:346–53.

  3. 3.

    Sulima A, Jalah R, Antoline JFG, Torres OB, Imler GH, Deschamps JR, et al. A stable heroin analogue that can serve as a vaccine hapten to induce antibodies that block the effects of heroin and its metabolites in rodents and that cross-react immunologically with related drugs of abuse. J Med Chem. 2018;61:329–43.

  4. 4.

    Raleigh MD, Peterson SJ, Laudenbach M, Baruffaldi F, Carroll FI, Comer SD, et al. Safety and efficacy of an oxycodone vaccine: addressing some of the unique considerations posed by opioid abuse. PLoS One. 2017;12:e0184876.

  5. 5.

    Hwang CS, Bremer PT, Wenthur CJ, Ho SO, Chiang S, Ellis B, et al. Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality. Mol Pharm. 2018;15:1062–72.

  6. 6.

    Laudenbach M, Baruffaldi F, Robinson C, Carter P, Seelig D, Baehr C, et al. Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose. Sci Rep. 2018;8:5508.

  7. 7.

    Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, et al. The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse. J Immunol. 2015;194:5926–36.

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This work is supported by a Hennepin Healthcare Research Institute award (M.P.), and by the NIH under grants U01 DA038876 (M.P.), R01 DA041730 (M.P.), and T32DA007097 (C.B.).

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Competing interests

M.P. is the inventor of “Cytokine Signaling Immunomodulators and Methods,” International Application No. PCT/US2017/031907 filed on May 10, 2017. C.B. declares no competing interests.

Correspondence to Marco Pravetoni.

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