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Are lithium effects dependent on genetic/epigenetic architecture?

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  1. 1.

    Fries GR, Colpo GD, Monroy-Jaramillo N, Zhao J, Zhao Z, Arnold JG, et al. Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder. Eur Neuropsychopharmacol. 2017;27:1110–9.

  2. 2.

    Kessing LV, Gerds TA, Knudsen NN, Jorgensen LF, Kristiansen SM, Voutchkova D, et al. Lithium in drinking water and the incidence of bipolar disorder: a nation-wide population-based study. Bipolar Disord. 2017;19:563–7.

  3. 3.

    Cruceanu C, Ambalavanan A, Spiegelman D, Gauthier J, Lafreniere RG, Dion PA, et al. Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder. Genome. 2013;56:634–40.

  4. 4.

    Huzayyin AA, Andreazza AC, Turecki G, Cruceanu C, Rouleau GA, Alda M, et al. Decreased global methylation in patients with bipolar disorder who respond to lithium. Int J Neuropsychopharmacol. 2014;17:561–9.

  5. 5.

    McGuire JL, Depasquale EA, Funk AJ, O’Donnovan SM, Hasselfeld K, Marwaha S, et al. Abnormalities of signal transduction networks in chronic schizophrenia. NPJ Schizophr. 2017;3:30.

  6. 6.

    Stern S, Santos R, Marchetto MC, Mendes APD, Rouleau GA, Biesmans S, et al. Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. Mol Psychiatry. 2018;23:1453–65.

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Funding for this study was provided by NIMH Advanced Center for Interventions and Services Research: Optimizing Outcomes in Bipolar Illness Interventions in Hispanic Communities P30MH086045.

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The authors declare no competing interests.

Correspondence to Consuelo Walss-Bass.

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