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Lipid signalling in the mesolimbic dopamine pathway

Neuropsychopharmacologyvolume 44pages221222 (2019) | Download Citation

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  1. 1.

    Tracey TJ, Steyn FJ, Wolvetang EJ, Ngo ST. Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease. Front Mol Neurosci. 2018;11:10. Jan 23

  2. 2.

    Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened mesolimbic dopamine function and signaling by saturated but not monounsaturated dietary lipids. Neuropsychopharmacology. 2015;41:811–21.

  3. 3.

    Décarie-Spain L, Sharma S, Hryhorczuk C, Issa-Garcia V, Barker PA, Arbour N, et al. Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Mol Metab. 2018;10:1–13.

  4. 4.

    Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, et al. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014;19:1095–105.

  5. 5.

    Hryhorczuk C, Sheng Z, Décarie-Spain L, Giguère N, Bourque M, Trudeau L-E, et al. Oleic acid in the ventral tegmental area inhibits feeding, food reward and dopamine tone. Neuropsychopharmacology. 2018;43:607–16.

  6. 6.

    Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, et al. Increased brain fatty acid uptake in metabolic syndrome. Diabetes. 2010;59:2171–7.

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SF and TA are both supported by FRQS scholar awards. Research was supported by a CIHR operating grant to SF (#275314). Many thanks to the Cecile Hryhorczuk, Léa Décarie-Spain and Sandeep Sharma for their hard work.

Author information


  1. Department of Nutrition, Centre de Recherche du CHUM, Université de Montréal & Montreal Diabetes Research Centre, Montréal, QC, Canada

    • Stephanie Fulton
  2. Department of Medicine, Université de Montréal & Montreal Diabetes Research Centre, Montréal, QC, Canada

    • Thierry Alquier


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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Stephanie Fulton.

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