Fig. 2 | Neuropsychopharmacology

Fig. 2

From: The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque

Fig. 2

The direction and magnitude of 5-HTP’s effects on attention are rooted in baseline behavior. a 5-HTP causes a bi-directional change in looking duration. 20 mg/kg (green) and 40 mg/kg (red) 5-HTP increases looking duration in animals with low baseline looking (dashed line) during saline sessions and decreases looking duration in high baseline looking animals (solid line). b (Top) Average looking duration for low and high baseline animals (grouped solid and dash lines from a). (Bottom) Average looking duration for low and high baseline animals after shuffling the drug labels within each animal. c 5-HTP significantly increases the magnitude change, the absolute value of the percent change, in looking duration relative to saline. d (Top) Baseline looking duration to images negatively correlates with percent change in looking duration due to 5-HTP (green, 20 mg/kg; red, 40 mg/kg). (Bottom) The average correlation from the shuffled data. In a, c, d, each shape represents an individual subject’s data

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