Fig. 7 | Mucosal Immunology

Fig. 7

From: Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines

Fig. 7

SmPill® containing whole-cell killed MS1342 V. cholerae together with CTB and α-GalCer elicit stronger faecal antigen-specific IgA titres than Dukoral®. Mice were immunized orally with SmPill® containing CTB and WCK MS1342 V. cholerae with or without α-GalCer as an adjuvant, or with Dukoral® in solution. Faecal pellets were collected on days 13, 27 and 41 and a Inaba-specific, b Ogawa LPS–specific and c CTB-specific IgA antibody titres were determined by end-point ELISA. Panels (df) present mean titres (+SEM) for five mice per experimental group at three time-points. Graphs (gi) present the mean areas under the curve (AUC) (+SEM) for each experimental group. Dukoral® versus SmPill®/no adjuvant versus α-GalCer: *p < 0.05, **p < 0.01, ***p < 0.001

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