Fig. 5 | Mucosal Immunology

Fig. 5

From: Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

Fig. 5

Potency of Ab-mediated trapping in six different individuals across multiple menstrual cycles. Donors 50 and 58 were normally cycling a-–f, while donors 21, 36, 43, and 57 were on birth control gr. Donor samples collected across multiple menstrual cycles were grouped to determine whether there was consistency in trapping potency within an individual, based on ensemble-averaged <Deff> (a, d, g, j, m, p) and percentage of fast-moving viruses b, e, h, k, n, q. Donor ID is presented on the left side of each set. Heat maps (C, f, i, l, g, r) show the proportion from CST I to CST V out of a total 100% of the sequenced microbiome, illustrating the inherent diversity of microbial populations both within an individual and across the menstrual cycle. Sample collection days are indicated on the left side of each heatmap. Microbes outside of CST I–V were classified as ‘Other’ O. Heatmap scale ranges from 0 (white) to 100% (black). Data was analyzed using One-Way ANOVA with Tukey’s Multiple Comparison’s test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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