Fig. 3 | Mucosal Immunology

Fig. 3

From: Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

Fig. 3

Effect of menstrual cycle phase and birth control status on Ab-mediated trapping of HSV-1 in pH-neutralized CVM. Six donors were followed across a minimum of two menstrual cycles and reported the number of days post-menses; cycles were normalized to 28 days. CVM samples were grouped by the cycle phase and separated by birth control status. Samples obtained during the follicular phase were those collected 6–14 days post-menses, while those collected during the luteal phase were from 15–28 days post-menses. At least two samples were collected during the follicular phase and two during the luteal phase from each donor. All Abs were tested at 5 µg/mL and compared with anti-Biotin IgG in matched samples. a Average <Deff> of virions in follicular versus luteal phase in NC versus BC donors. b Percentage of fast-moving virions (average <Deff> ≥ 0.347 µm2/s) by phase in follicular versus luteal phase in normally cycling (NC) versus donors on birth control (BC). Data was analyzed using Two-Way ANOVA with Sidak’s multiple comparisons test. A p ≤ 0.05 was considered statistically significant (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). N = 32 follicular phase samples, N = 38 luteal phase samples

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