Fig. 4 | Mucosal Immunology

Fig. 4

From: Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy

Fig. 4

Dual checkpoints for tolerance to airborne antigens. A new model of two connected but mechanistically independent checkpoints regulating tolerance and the susceptibility to allergies: the first and dominant checkpoint is set by the proteins’ capacity to induce Treg or escape Treg control. The second checkpoint is determined by the Th2-forming capacity of those proteins escaping Treg control. Although both checkpoints have a different mechanistic basis they are both susceptible to protein-intrinsic as well as patient-specific factors (see main text for details). Treg-inducing and Th2-inducing capacity may vary between individuals, increasing the risk for allergy development

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