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The universe is asymmetric, the mouse brain too

Molecular Psychiatry (2024)Cite this article

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Abstract

Hemispheric brain asymmetry is a basic organizational principle of the human brain and has been implicated in various psychiatric conditions, including autism spectrum disorder. Brain asymmetry is not a uniquely human feature and is observed in other species such as the mouse. Yet, asymmetry patterns are generally nuanced, and substantial sample sizes are required to detect these patterns. In this pre-registered study, we use a mouse dataset from the Province of Ontario Neurodevelopmental Network, which comprises structural MRI data from over 2000 mice, including genetic models for autism spectrum disorder, to reveal the scope and magnitude of hemispheric asymmetry in the mouse. Our findings demonstrate the presence of robust hemispheric asymmetry in the mouse brain, such as larger right hemispheric volumes towards the anterior pole and larger left hemispheric volumes toward the posterior pole, opposite to what has been shown in humans. This suggests the existence of species-specific traits. Further clustering analysis identified distinct asymmetry patterns in autism spectrum disorder models, a phenomenon that is also seen in atypically developing participants. Our study shows potential for the use of mouse models to understand the biological bases of typical and atypical brain asymmetry but also warrants caution as asymmetry patterns seem to differ between humans and mice.

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Fig. 1: Asymmetry index in wild-type.
Fig. 2: Selected model comparisons to wild-type controls.
Fig. 3: Clustering wild-type > transgenic contrasts.

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Acknowledgements

This project was supported by the Horizon Europe programs CANDY under grant agreement nos. 847818 to JG and JRH.

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Author notes

  1. These authors contributed equally: Sabrina van Heukelum, Joanes Grandjean.

Authors and Affiliations

  1. Donders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands

    Alejandro Rivera-Olvera, Danielle J. Houwing, Shang Masifi, Stephany LL. Martina, Clyde Francks, Judith R. Homberg, Sabrina van Heukelum & Joanes Grandjean

  2. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands

    Danielle J. Houwing & Clyde Francks

  3. Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, M5T 3H7, Canada

    Jacob Ellegood & Jason P. Lerch

  4. Department of Genetics, Harvard Medical School, Boston, MA, USA

    Andrew Silberfeld & Olivier Pourquie

  5. Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA

    Andrew Silberfeld & Olivier Pourquie

  6. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

    Olivier Pourquie

  7. Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, Oxfordshire, OX39DU, UK

    Jason P. Lerch

  8. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

    Clyde Francks

  9. Department for Medical Imaging, Radboud University Medical Center, PO Box 9101, Nijmegen, The Netherlands

    Joanes Grandjean

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  1. Alejandro Rivera-Olvera
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Contributions

Alejandro Rivera-Olvera - Conceptualization, Formal Analysis, Writing – Original Draft; Danielle J. Houwing - Conceptualization, Writing – Review & Editing; Jacob Ellegood - Data Curation, Writing – Review & Editing; Shang Masifi - Writing – Review & Editing; Stephany LL. Martina - Writing – Review & Editing; Andrew Silberfeld - Conceptualization, Writing – Review & Editing; Olivier Pourquie - Conceptualization, Writing – Review & Editing; Jason P. Lerch - Funding Acquisition, Writing – Review & Editing; Clyde Francks - Conceptualization, Supervision, Writing – Review & Editing; Judith R. Homberg - Funding Acquisition, Supervision, Writing – Review & Editing; Sabrina van Heukelum - Conceptualization, Formal Analysis, Supervision, Writing – Original Draft; Joanes Grandjean - Conceptualization, Formal Analysis, Funding Acquisition, Software, Supervision, Visualization, Writing – Original Draft

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Correspondence to Joanes Grandjean.

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Rivera-Olvera, A., Houwing, D.J., Ellegood, J. et al. The universe is asymmetric, the mouse brain too. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02687-2

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