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Addiction biotypes: a paradigm shift for future treatment strategies?

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  1. Pettorruso M, di Giannantonio M, De Risio L, Martinotti G, Koob GF. A light in the darkness: repetitive transcranial magnetic stimulation (rTMS) to treat the hedonic dysregulation of addiction. J Addict Med. 2020;14:272–4.

    Article  PubMed  PubMed Central  Google Scholar 

  2. UNODC, World Drug Report 2023 (United Nations publication, 2023).

  3. Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, et al. Neurofunctional domains derived from deep behavioral phenotyping in alcohol use disorder. Am J Psychiatry. 2019;176:744–53.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Brucar LR, Feczko E, Fair DA, Zilverstand A. Current approaches in computational psychiatry for the data-driven identification of brain-based subtypes. Biol Psychiatry. 2023;93:704–16.

    Article  PubMed  Google Scholar 

  5. Clementz BA, Sweeney JA, Hamm JP, Ivleva EI, Ethridge LE, Pearlson GD, et al. Identification of distinct psychosis biotypes using brain-based biomarkers. Am J Psychiatry. 2016;173:373–84.

    Article  PubMed  Google Scholar 

  6. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 2012;486:346–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Drysdale AT, Grosenick L, Downar J, Dunlop K, Mansouri F, Meng Y, et al. Resting-state connectivity biomarkers define neuro- physiological subtypes of depression. Nat Med. 2017;23:28–38. [published correction appears in Nat Med 2017;23:264]

    Article  CAS  PubMed  Google Scholar 

  8. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine D, Quinn K, et al. Research domain criteria (rdoc): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167:748–51.

    Article  PubMed  Google Scholar 

  9. Bogdan R, Hatoum AS, Johnson EC, Agrawal A. The genetically informed neurobiology of addiction (GINA) model. Nat Rev Neurosci. 2023;24:40–57.

    Article  CAS  PubMed  Google Scholar 

  10. Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders. Biol Psychiatry. 2016;80:179–89.

    Article  PubMed  Google Scholar 

  11. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

    Article  PubMed  Google Scholar 

  12. Witkiewitz K, Stein ER, Votaw VR, Hallgren KA, Gibson BC, Boness CL, et al. Constructs derived from the addiction cycle predict alcohol use disorder treatment outcomes and recovery 3 years following treatment. Psychol Addict Behav. 2023;37:376–89.

    Article  PubMed  Google Scholar 

  13. Zhu T, Becquey C, Chen Y, Lejuez CW, Li CR, Bi J. Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations. Transl Psychiatry. 2022;12:253.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Voon V, Grodin E, Mandali A, Morris L, Doñamayor N, Weidacker K, et al. Addictions neuroimaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder. Neurosci Biobehav Rev. 2020;113:492–506.

    Article  PubMed  Google Scholar 

  15. Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, et al. Precision medicine in alcohol dependence: a controlled trial testing pharmacotherapy response among reward and relief drinking phenotypes. Neuropsychopharmacology. 2018;43:891–9.

    Article  PubMed  Google Scholar 

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Conceptualization: MP; Investigation: FDC, GdA; Methodology: MP, GDL, LDR; Writing - original draft: MP, LDR, FDC, GdA; Writing - review and editing: GDL, GM.

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Correspondence to Mauro Pettorruso.

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Pettorruso, M., Di Lorenzo, G., De Risio, L. et al. Addiction biotypes: a paradigm shift for future treatment strategies?. Mol Psychiatry 29, 1450–1452 (2024).

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