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Does the human ventromedial prefrontal cortex support fear learning, fear extinction or both? A commentary on subregional contributions

Current models of human fear learning processes emphasize a primary contribution of the ventromedial prefrontal cortex (vmPFC) to fear inhibition (i.e., fear extinction). Here, we discuss crucial findings from recent brain imaging studies that highlight the role of vmPFC and its subregions in how fear is acquired (i.e., fear conditioning).

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Fig. 1: The ventromedial prefrontal cortex in fear conditioning.


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SB and MAF conceived the idea. SB wrote the manuscript, MAF and BH provided revisions. All authors approved the final version of the manuscript.

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Correspondence to Simone Battaglia or Miquel A. Fullana.

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The authors declare no competing interests.

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Battaglia, S., Harrison, B.J. & Fullana, M.A. Does the human ventromedial prefrontal cortex support fear learning, fear extinction or both? A commentary on subregional contributions. Mol Psychiatry 27, 784–786 (2022).

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