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Resting-state neuroimaging in social anxiety disorder: a systematic review

Molecular Psychiatry volume 27, pages 164–179 (2022)Cite this article

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Abstract

There has been a growing interest in resting-state brain alterations in people with social anxiety disorder. However, the evidence has been mixed and contested and further understanding of the neurobiology of this disorder may aid in informing methods to increase diagnostic accuracy and treatment targets. With this systematic review, we aimed to synthesize the findings of the neuroimaging literature on resting-state functional activity and connectivity in social anxiety disorder, and to summarize associations between brain and social anxiety symptoms to further characterize the neurobiology of the disorder. We systematically searched seven databases for empirical research studies. Thirty-five studies met the inclusion criteria, with a total of 1611 participants (795 people with social anxiety disorder and 816 controls). Studies involving resting-state seed-based functional connectivity analyses were the most common. Individuals with social anxiety disorder (vs. controls) displayed both higher and lower connectivity between frontal–amygdala and frontal–parietal regions. Frontal regions were the most consistently implicated across other analysis methods, and most associated with social anxiety symptoms. Small sample sizes and variation in the types of analyses used across studies may have contributed to the inconsistencies in the findings of this review. This review provides novel insights into established neurobiological models of social anxiety disorder and provides an update on what is known about the neurobiology of this disorder in the absence of any overt tasks (i.e., resting state). The knowledge gained from this body of research enabled us to also provide recommendations for a more standardized imaging pre-processing approach to examine resting-state brain activity and connectivity that could help advance knowledge in this field. We believe this is warranted to take the next step toward clinical translation in social anxiety disorder that may lead to better treatment outcomes by informing the identification of neurobiological targets for treatment.

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Fig. 1: Preferred reporting items for systematic reviews and meta-analyses flowchart for systematic search and identification of studies meeting inclusion criteria for the systematic review.
Fig. 2: Differences in positive functional connectivity between groups.

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Acknowledgements

This work was supported by the Australian Government Research Training Program Scholarship (SM).

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Authors and Affiliations

  1. Healthy Brain and Mind Research Centre, School of Behavioral and Health Sciences, Australian Catholic University, Fitzroy, Melbourne, Australia

    Simone Mizzi & Izelle Labuschagne

  2. Department of Psychology and Neuroscience, Auckland University of Technology, Auckland, New Zealand

    Mangor Pedersen

  3. Neuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioral and Health Sciences, Australian Catholic University, Fitzroy, Melbourne, Australia

    Valentina Lorenzetti

  4. Freiburg Brain Imaging Center, University Medical Center, Albert-Ludwigs University of Freiburg, Freiburg, Germany

    Markus Heinrichs

  5. Department of Psychology, Albert-Ludwigs University of Freiburg, Freiburg, Germany

    Markus Heinrichs

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Mizzi, S., Pedersen, M., Lorenzetti, V. et al. Resting-state neuroimaging in social anxiety disorder: a systematic review. Mol Psychiatry 27, 164–179 (2022). https://doi.org/10.1038/s41380-021-01154-6

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