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Unravelling the complexities of depression with medical intelligence: exploring the interplay of genetics, hormones, and brain function
Complex & Intelligent Systems Open Access 04 April 2024
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References
Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry. 1965;122:509–22.
Bunney WE Jr., Davis JM. Norepinephrine in depressive reactions. A review. Arch Gen Psychiatry. 1965;13:483–94.
Gold PW, Wong ML, Goldstein DS, Gold HK, Ronsaville DS, Esler M, et al. Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. Proc Natl Acad Sci USA. 2005;102:8303–8.
Wong ML, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, et al. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci USA. 2000;97:325–30.
Gold PW. The organization of the stress system and its dysregulation in depressive illness. Mol Psychiatry. 2015;20:32–47.
Calogero AE, Gallucci WT, Chrousos GP, Gold PW. Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro. J Clin Investig. 1988;82:839–46.
McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, et al. CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron. 2015;87:605–20.
Huang YH, Maas JW, Hu GH. The time course of noradrenergic pre- and postsynaptic activity during chronic desipramine treatment. Eur J Pharm. 1980;68:41–7.
Grant MM, Weiss JM. Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity. Biol Psychiatry. 2001;49:117–29.
Brady LS, Whitfield HJ Jr., Fox RJ, Gold PW, Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J Clin Investig. 1991;87:831–7.
Vetulani J, Stawarz RJ, Dingell JV, Sulser F. A possible common mechanism of action of antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP gererating system in the rat limbic forebrain. Naunyn Schmiedebergs Arch Pharm. 1976;293:109–14.
Davies DL, Shepherd M. Reserpine in the treatment of anxious and depressed patients. Lancet. 1955;269:117–20.
Price LH, Charney DS, Heninger GR. Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects. Psychopharmacol (Berl). 1987;92:431–7.
Axelrod J, Whitby LG, Hertting G. Effect of psychotropic drugs on the uptake of H3-norepinephrine by tissues. Science. 1961;133:383–4.
Gold PW, Chrousos GP. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Proc Assoc Am Phys. 1999;111:22–34.
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Gold, P.W., Wong, ML. Re-assessing the catecholamine hypothesis of depression: the case of melancholic depression. Mol Psychiatry 26, 6121–6124 (2021). https://doi.org/10.1038/s41380-021-01133-x
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DOI: https://doi.org/10.1038/s41380-021-01133-x
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Unravelling the complexities of depression with medical intelligence: exploring the interplay of genetics, hormones, and brain function
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