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A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression

Molecular Psychiatry volume 25, pages 1312–1322 (2020)Cite this article

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Abstract

Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and the results are difficult to replicate. Previous animal studies have shown that knockout of the serotonin receptor 7 gene (HTR7) resulted in an antidepressant-like phenotype, suggesting it was important to antidepressant action. In this report, in the first stage, we used a cost-effective pooled-sequencing strategy to sequence the entire HTR7 gene and its regulatory regions to investigate the association of common variants in HTR7 and clinical response to four selective serotonin reuptake inhibitors (SSRIs: citalopram, paroxetine, fluoxetine and sertraline) in a retrospective cohort mainly consisting of subjects with bipolar disorder (n = 359). We found 80 single-nucleotide polymorphisms (SNPs) with false discovery rate < 0.05 associated with response to paroxetine. Among the significant SNPs, rs7905446 (T/G), which is located at the promoter region, also showed nominal significance (P < 0.05) in fluoxetine group. GG/TG genotypes for rs7905446 and female gender were associated with better response to two SSRIs (paroxetine and fluoxetine). In the second stage, we replicated this association in two independent prospective samples of SSRI-treated patients with major depressive disorder: the MARS (n = 253, P = 0.0169) and GENDEP studies (n = 432, P = 0.008). The GG/TG genotypes were consistently associated with response in all three samples. Functional study of rs7905446 showed greater activity of the G allele in regulating expression of HTR7. The G allele displayed higher luciferase activity in two neuronal-related cell lines, and estrogen treatment decreased the activity of only the G allele. Electrophoretic mobility shift assay suggested that the G allele interacted with CCAAT/enhancer-binding protein beta transcription factor (TF), while the T allele did not show any interaction with any TFs. Our results provided novel pharmacogenomic evidence to support the role of HTR7 in association with antidepressant response.

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References

  1. Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res. 2008;195:198–213.

    Article  CAS  PubMed  Google Scholar 

  2. Nichols DE, Nichols CD. Serotonin receptors. Chem Rev. 2008;108:1614–41.

    Article  CAS  PubMed  Google Scholar 

  3. Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, et al. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci USA. 1993;90:8547–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993;268:23422–6.

    CAS  PubMed  Google Scholar 

  5. Neumaier JF, Sexton TJ, Yracheta J, Diaz AM, Brownfield M. Localization of 5-HT(7) receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression. J Chem Neuroanat. 2001;21:63–73.

    Article  CAS  PubMed  Google Scholar 

  6. Varnas K, Thomas DR, Tupala E, Tiihonen J, Hall H. Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970. Neurosci Lett. 2004;367:313–6.

    Article  CAS  PubMed  Google Scholar 

  7. Beattie DT, Smith JA. Serotonin pharmacology in the gastrointestinal tract: a review. Naunyn Schmiede Arch Pharmacol. 2008;377:181–203.

    Article  CAS  Google Scholar 

  8. East SZ, Burnet PW, Kerwin RW, Harrison PJ. An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. Schizophr Res. 2002;57:15–26.

    Article  CAS  PubMed  Google Scholar 

  9. Mowry BJ, Ewen KR, Nancarrow DJ, Lennon DP, Nertney DA, Jones HL, et al. Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample. Am J Med Genet. 2000;96:864–9.

    Article  CAS  PubMed  Google Scholar 

  10. Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, et al. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology. 2006;31:866–71.

    Article  CAS  PubMed  Google Scholar 

  11. Hedlund PB, Sutcliffe JG. The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. Neurosci Lett. 2007;414:247–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ballaz SJ, Akil H, Watson SJ. Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior. Neuroscience. 2007;147:428–38.

    Article  CAS  PubMed  Google Scholar 

  13. Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, et al. Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression. Neuropharmacology. 2005;48:492–502.

    Article  CAS  PubMed  Google Scholar 

  14. Sarkisyan G, Roberts AJ, Hedlund PB. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behav Brain Res. 2010;209:99–108.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG. 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern. Biol Psychiatry. 2005;58:831–7.

    Article  CAS  PubMed  Google Scholar 

  16. Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E. Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression. Neuropharmacology. 2006;51:578–86.

    Article  CAS  PubMed  Google Scholar 

  17. Swanson G, Miller S, Alyahyawi A, Wilson B, Saadatmand F, Lee C. et al. Genetic polymorphisms in the serotonin receptor 7 (HTR7) gene are associated with cortisol levels in African American young adults [version 1; referees: 1 not approved]. F1000Research. 2017;6:19

    Article  Google Scholar 

  18. Mullins UL, Gianutsos G, Eison AS. Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus. Neuropsychopharmacology. 1999;21:352–67.

    Article  CAS  PubMed  Google Scholar 

  19. Sleight AJ, Carolo C, Petit N, Zwingelstein C, Bourson A. Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol Pharmacol. 1995;47:99–103.

    CAS  PubMed  Google Scholar 

  20. Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ Jr., et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994;268:1403–10.

    CAS  PubMed  Google Scholar 

  21. Monsma FJ Jr., Shen Y, Ward RP, Hamblin MW, Sibley DR. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993;43:320–7.

    CAS  PubMed  Google Scholar 

  22. Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology (Berl). 2009;205:119–28.

    Article  CAS  Google Scholar 

  23. Ishibashi T, Horisawa T, Tokuda K, Ishiyama T, Ogasa M, Tagashira R, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010;334:171–81.

    Article  CAS  PubMed  Google Scholar 

  24. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163:1905–17.

    Article  PubMed  Google Scholar 

  25. Sharma V, Khan M, Smith A. A closer look at treatment resistant depression: is it due to a bipolar diathesis? J Affect Disord. 2005;84:251–7.

    Article  PubMed  Google Scholar 

  26. Martinsson L, Wei Y, Xu D, Melas PA, Mathe AA, Schalling M, et al. Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres. Transl Psychiatry. 2013;3:e261.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Post RM, Leverich GS, Nolen WA, Kupka RW, Altshuler LL, Frye MA, et al. A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network. Bipolar Disord. 2003;5:396–406.

    Article  PubMed  Google Scholar 

  28. Vazquez GH, Tondo L, Undurraga J, Baldessarini RJ. Overview of antidepressant treatment of bipolar depression. Int J Neuropsychopharmacol. 2013;16:1673–85.

    Article  CAS  PubMed  Google Scholar 

  29. Uher R, Perroud N, Ng MY, Hauser J, Henigsberg N, Maier W, et al. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry. 2010;167:555–64.

    Article  PubMed  Google Scholar 

  30. Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, et al. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry. 2009;66:966–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, et al. A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry. 2010;67:133–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry. 1994;51:849–59. discussion 863-4

    Article  PubMed  Google Scholar 

  33. Andrews S. FastQC: a quality control tool for high throughput sequence data. 2015. https://www.bioinformatics.babraham.ac.uk/projects/fastqc/.

  34. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009;25:2078–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  35. Bansal V. A statistical method for the detection of variants from next-generation resequencing of DNA pools. Bioinformatics. 2010;26:i318–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38:e164.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Hennings JM, Owashi T, Binder EB, Horstmann S, Menke A, Kloiber S, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res. 2009;43:215–29.

    Article  PubMed  Google Scholar 

  38. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, et al. Genetic predictors of response to antidepressants in the GENDEP project. Pharm J. 2009;9:225–33.

    CAS  Google Scholar 

  40. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–9.

    Article  CAS  PubMed  Google Scholar 

  41. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278–96.

    Article  CAS  PubMed  Google Scholar 

  42. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71.

    Article  CAS  PubMed  Google Scholar 

  43. Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, et al. Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies. Eur Neuropsychopharmacol. 2018;28:945–54.

    Article  CAS  PubMed  Google Scholar 

  44. Uher R, Maier W, Hauser J, Marusic A, Schmael C, Mors O, et al. Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry. 2009;194:252–9.

    Article  PubMed  Google Scholar 

  45. Wei YB, Martinsson L, Liu JJ, Forsell Y, Schalling M, Backlund L, et al. hTERT genetic variation in depression. J Affect Disord. 2016;189:62–9.

    Article  CAS  PubMed  Google Scholar 

  46. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Mink S, Haenig B, Klempnauer KH. Interaction and functional collaboration of p300 and C/EBPbeta. Mol Cell Biol. 1997;17:6609–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol. 1995;15:4971–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Montgomery S, Hansen T, Kasper S. Efficacy of escitalopram compared to citalopram: a meta-analysis. Int J Neuropsychopharmacol. 2011;14:261–8.

    Article  CAS  PubMed  Google Scholar 

  50. Marken PA, Munro JS. Selecting a selective serotonin reuptake inhibitor: clinically important distinguishing features. Prim Care Companion J Clin Psychiatry. 2000;2:205–10.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Martenyi F, Dossenbach M, Mraz K, Metcalfe S. Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients: a double-blind trial of antidepressants with serotonergic or norepinephrinergic reuptake inhibition profile. Eur Neuropsychopharmacol. 2001;11:227–32.

    Article  CAS  PubMed  Google Scholar 

  52. Keers R, Aitchison KJ. Gender differences in antidepressant drug response. Int Rev Psychiatry. 2010;22:485–500.

    Article  PubMed  Google Scholar 

  53. Diflorio A, Jones I. Is sex important? Gender differences in bipolar disorder. Int Rev Psychiatry. 2010;22:437–52.

    Article  PubMed  Google Scholar 

  54. Estrada-Camarena E, Lopez-Rubalcava C, Vega-Rivera N, Recamier-Carballo S, Fernandez-Guasti A. Antidepressant effects of estrogens: a basic approximation. Behav Pharmacol. 2010;21:451–64.

    Article  CAS  PubMed  Google Scholar 

  55. Speranza L, Chambery A, Di Domenico M, Crispino M, Severino V, Volpicelli F, et al. The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways. Neuropharmacology. 2013;67:155–67.

    Article  CAS  PubMed  Google Scholar 

  56. Speranza L, Labus J, Volpicelli F, Guseva D, Lacivita E, Leopoldo M, et al. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. J Neurochem. 2017;141:647–61.

    Article  CAS  PubMed  Google Scholar 

  57. de las Casas-Engel M, Dominguez-Soto A, Sierra-Filardi E, Bragado R, Nieto C, Puig-Kroger A, et al. Serotonin skews human macrophage polarization through HTR2B and HTR7. J Immunol. 2013;190:2301–10.

    Article  CAS  Google Scholar 

  58. Strawbridge R, Arnone D, Danese A, Papadopoulos A, Herane Vives A, Cleare AJ. Inflammation and clinical response to treatment in depression: a meta-analysis. Eur Neuropsychopharmacol. 2015;25:1532–43.

    Article  CAS  PubMed  Google Scholar 

  59. Ciranna L, Catania MV. 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders. Front Cell Neurosci. 2014;8:250.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  60. Renner U, Zeug A, Woehler A, Niebert M, Dityatev A, Dityateva G, et al. Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. J Cell Sci. 2012;125(Pt 10):2486–99.

    Article  CAS  PubMed  Google Scholar 

  61. Naumenko VS, Popova NK, Lacivita E, Leopoldo M, Ponimaskin EG. Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. CNS Neurosci Ther. 2014;20:582–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 2010;62:72–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Salloum NC, McCarthy MJ, Leckband SG, Kelsoe JR. Towards the clinical implementation of pharmacogenetics in bipolar disorder. BMC Med. 2014;12:90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgements

This work was supported by grants to JRK from the NIMH (U01 MH92758) and the Department of Veterans Affairs and UCSD CTRI Pilot Project Grant (to MM and JRK). YBW was supported by the Swedish Research Council (Reg no. 2015–06372). HR was supported by the Alberta Centennial Addiction and Mental Health Research Chair held by KJA. GENDEP was funded by a European Commission Framework 6 grant (Contract Ref: LSHB-CT-2003503428). Lundbeck provided both nortriptyline and escitalopram free of charge. GlaxoSmithKline, the Medical Research Council and the Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King’s College London and South London and Maudsley NHS Foundation Trust (funded by the National Institute for Health Research, Department of Health, UK) contributed by funding add-on projects in the London center. A joint grant from the Medical Research Council, UK, and GlaxoSmithKline (G0701420) provided additional funding for the array genotyping. The funders had no role in the design and conduct of the study, in data collection, analysis, interpretation or writing the report. MARS samples were supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e: Med Programme (grant 01ZX1314J to EBB).

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Authors and Affiliations

  1. Center for Molecular Medicine, Karolinska University Hospital, 17176, Stockholm, Sweden

    Ya Bin Wei & Susan G. Leckband

  2. Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176, Stockholm, Sweden

    Ya Bin Wei

  3. Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA

    Ya Bin Wei, Michael McCarthy, Tatyana Shekhtman, Anna DeModena & John R. Kelsoe

  4. Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, 92161, USA

    Michael McCarthy, Tatyana Shekhtman, Anna DeModena, Susan G. Leckband & John R. Kelsoe

  5. Psychiatric Laboratory and Mental Health Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China

    Hongyan Ren

  6. Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada

    Hongyan Ren & Katherine J. Aitchison

  7. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany

    Tania Carrillo-Roa & Elisabeth B. Binder

  8. National Institute on Drug Dependence, Peking University, 100191, Beijing, China

    Jia Jia Liu

  9. Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospita, Peking University, 100191, Beijing, China

    Jia Jia Liu

  10. Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark

    Ole Mors

  11. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim Heidelberg University, Mannheim, Germany

    Marcella Rietschel

  12. Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb School of Medicine, Zagreb, Croatia

    Neven Henigsberg

  13. Biological Psychiatry Unit, IRCCS, Brescia, Italy

    Annamaria Cattaneo

  14. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Elisabeth B. Binder

  15. Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA

    John R. Kelsoe

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KJA has been a member of various advisory boards, received consultancy fees and honoraria, and received research grants from companies including Johnson and Johnson Pharmaceuticals Research and Development, Bristol-Myers Squibb Pharmaceuticals Limited, and Janssen Inc., Canada. MM serves as scientific consultant to Janssen Pharmaceuticals. EBB receives a research grant from Böhringer Ingelheim.

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Wei, Y.B., McCarthy, M., Ren, H. et al. A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. Mol Psychiatry 25, 1312–1322 (2020). https://doi.org/10.1038/s41380-019-0397-1

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