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Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats

Molecular Psychiatry volume 25, pages 896–905 (2020)Cite this article

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Abstract

Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.

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Acknowledgements

We thank Renate Winter and Doris Zschaber for excellent technical assistance and Susanne Müller for profound support on MRI studies.

Funding

This research was supported by the BMBF, Germany (01EE1403A+C (GCBS), 01EW1409 (EraNet Neuron, RD_aDBS). FW, BH, EBH were/are financed by the DFG, Germany (WI 2140/1-1/2; WI 2140/3-1).

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany

    Ravit Hadar, Henriette Edemann-Callesen, Franziska Wieske, Bettina Habelt, Elizabeth Barroeta-Hlusicka, Cristian Alexandru Tatarau & Christine Winter

  2. Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

    Ravit Hadar, Rebecca Winter, Henriette Edemann-Callesen, Bettina Habelt, Viktoria Felgel-Farnholz, Elizabeth Barroeta-Hlusicka, Nadine Bernhardt & Christine Winter

  3. International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany

    Henriette Edemann-Callesen

  4. Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, 10031, USA

    Niranjan Khadka & Marom Bikson

  5. Department of Neurology, University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany

    Janine Reis & Brita Fritsch

  6. Department of Neurophysiology, Medical School of the Ruhr-Universität Bochum, Bochum, Germany

    Klaus Funke

  7. Department Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany

    Michael A. Nitsche

  8. Department Neurology, University Hospital Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany

    Michael A. Nitsche

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  1. Ravit Hadar
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Correspondence to Christine Winter.

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Hadar, R., Winter, R., Edemann-Callesen, H. et al. Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats. Mol Psychiatry 25, 896–905 (2020). https://doi.org/10.1038/s41380-019-0356-x

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