Fig. 2 | Molecular Psychiatry

Fig. 2

From: NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity

Fig. 2

Rapid ketamine action in fast-spiking PV-cells. a Representative raster plots of fast-spiking cells in V1 recorded in vivo at baseline and 5 min post-ketamine injection (top). Firing rate changes in these putative inhibitory cells recorded in response to visual gratings (n = 17, Wilcoxon matched paired test, p = 0.038) (bottom). b Representative NMDA receptor-mediated excitatory post-synaptic currents (EPSCNMDA) recorded from PV-cells in vitro in WT males at baseline (black traces), 15 min after bath application of ketamine (10 µM, purple line) then CPP/AP5 (gray trace). c Quantification of EPSCNMDA amplitude normalized to baseline (mean ± sem, n = 9 cells, 6 mice; matched paired test, F = 5.85, p = 0.042). d Representative in situ hybridization images from WT mice depicting co-localization of grin2A and interneuron marker (Pvalb) in visual cortex. e Integrated density (IntDen) of Pvalb and grin2A in PV-positive cells (median ± 95% CI, n = 62 cells). f Positive correlation between Pvalb and grin2A expression (Spearman p = 0.0005)

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