Limits to human neurogenesis—really?

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  1. 1.

    Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555:377–81.

  2. 2.

    Bao A-M, Swaab DF. The art of matching brain tissue from patients and controls for postmortem research. Handb Clin Neurol. 2018;150:197–217.

  3. 3.

    Gonzalez-Riano C, Tapia-González S, García A, Muñoz A, DeFelipe J, Barbas C. Metabolomics and neuroanatomical evaluation of post-mortem changes in the hippocampus. Brain Struct Funct. 2017;222:2831–53.

  4. 4.

    Boekhoorn K, Joels M, Lucassen PJ. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiol Dis. 2006;24:1–14.

  5. 5.

    Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, et al. Individual case analysis of postmortem interval time on brain tissue preservation. PLoS ONE. 2016;11:e0151615.

  6. 6.

    Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, et al. Rapid trimming of cell surface polysialic acid (PolySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin. J Biol Chem. 2015;290:13202–14.

  7. 7.

    Ryan SM, Nolan YM. Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate? Neurosci Biobehav Rev. 2016;61:121–31.

  8. 8.

    Lucassen PJ, Oomen CA, Naninck EF, Fitzsimons CP, van Dam AM, Czeh B, et al. Regulation of adult neurogenesis and plasticity by (early)stress, glucocorticoids, and inflammation. Cold Spring Harb Perspect Biol. 2015;7:a021303.

  9. 9.

    Chawana R, Alagaili A, Patzke N, Spocter MA, Mohammed OB, Kaswera C, et al. Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin. Neuroscience. 2014;277:724–33.

  10. 10.

    Amrein I, Dechmann DK, Winter Y, Lipp HP. Absent or low rate of adult neurogenesis in the hippocampus of bats (Chiroptera). PLoS ONE. 2007;2:e455.

  11. 11.

    Erkut ZA, Klooker T, Endert E, Huitinga I, Swaab DF. Stress of dying is not suppressed by high-dose morphine or by dementia. Neuropsychopharm. 2004;29:152–7.

  12. 12.

    Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, et al. Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell. 2018;22:589–99.

  13. 13.

    Jessberger S, Parent JM. Epilepsy and adult neurogenesis. Cold Spring Harb Perspect Biol. 2015;7:a020677.

  14. 14.

    Verwer RW, Sluiter AA, Balesar RA, Baayen JC, Speijer D, Idema S, et al. Altered loyalties of neuronal markers in cultured slices of resected human brain tissue. Brain Pathol. 2016;26:523–32.

  15. 15.

    Wu MV, Sahay A, Duman RS, Hen R. Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus. Cold Spring Harb Perspect Biol. 2015;7:a018978.

  16. 16.

    Puyal J, Ginet V, Clarke PG. Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection. Prog Neurobiol. 2013;105:24–48.

  17. 17.

    Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, et al. Human adult neurogenesis: evidence and remaining questions. Cell Stem Cell. 2018;S1934-5909:30166–8.

  18. 18.

    Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. Does Adult Neurogenesis Persist in the Human Hippocampus? Cell Stem Cell. 2018;23:780–1.

  19. 19.

    Tartt AN, Fulmore CA, Liu Y, Rosoklija GB, Dwork AJ, Arango V, et al. Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain. Cell Stem Cell. 23:782–3.

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Correspondence to Paul J. Lucassen.

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