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Response to lithium has a neurobiological signature

Molecular Psychiatry volume 25, pages 509–510 (2020)Cite this article

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To the editor

A recently published report by the Bipolar Disorder Working Group of the ENIGMA Consortium has analyzed neuroimaging data on 6503 individuals, providing compelling evidence for the existence of a cumulative degenerative effect of bipolar disorder (BD) on the cortex of affected patients [1]. Their conclusion that patients have decreased cortical thickness than unaffected individuals and that this effect is moderated by duration of disease endorses several previous studies that identified that the disorder is characterized by evident clinical neuroprogression [2].

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Acknowledgements

We thank the financial support of Fundo de Incentivo à Pesquisa from Hospital de Clínicas de Porto Alegre (FIPE/HCPA) for funding the work for this study and letter.

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Authors and Affiliations

  1. Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

    Arthur Caye, Ives C. Passos, Mauricio Kunz & Marcia Kauer-Sant’anna

  2. Post-Graduate Program in Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Arthur Caye, Ives C. Passos, Mauricio Kunz & Marcia Kauer-Sant’anna

  3. Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Ives C. Passos, Mauricio Kunz & Marcia Kauer-Sant’anna

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  1. Arthur Caye
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  2. Ives C. Passos
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Correspondence to Arthur Caye.

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Conflict of interest

ICP has received consulting fees from Torrent/Omnifarma. MK has received consulting or speaking fees from Daichii Sankyo. He has received research grants from CNPq. MK-S has received consulting or speaking fees from Daichii Sankyo and Shire. She has received research grants from CNPq/CAPES. AC declares that he has no conflict of interest.

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Caye, A., Passos, I.C., Kunz, M. et al. Response to lithium has a neurobiological signature. Mol Psychiatry 25, 509–510 (2020). https://doi.org/10.1038/s41380-018-0050-4

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