Lithium treatment and mechanisms of aging

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  1. 1.

    Ahrens B, Muller-Oerlinghausen B. Does lithium exert an independent antisuicidal effect? Pharmacopsychiatry. 2001;34:132–6.

  2. 2.

    Cipriani A, Pretty H, Hawton K, Geddes JR. Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials. Am J Psychiatry. 2005;162:1805–19.

  3. 3.

    Smith EG, Austin KL, Kim HM, Eisen SV, Kilbourne AM, Miller DR, et al. Mortality associated with lithium and valproate treatment of US Veterans Health Administration patients with mental disorders. Br J Psychiatry. 2015;207:55–63.

  4. 4.

    Ahrens B, Grof P, Moller HJ, Muller-Oerlinghausen B, Wolf T. Extended survival of patients on long-term lithium treatment. Can J Psychiatry. 1995;40:241–6.

  5. 5.

    Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M. Low-dose lithium uptake promotes longevity in humans and metazoans. Eur J Nutr. 2011;50:387–9.

  6. 6.

    McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008;283:350–7.

  7. 7.

    Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, et al. Lithium promotes longevity through GSK3/NRF2-dependent Hormesis. Cell Rep. 2016;15:638–50.

  8. 8.

    Zmijewski JW, Jope RS. Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts. Aging Cell. 2004;3:309–17.

  9. 9.

    Squassina A, Pisanu C, Congiu D, Caria P, Frau D, Niola P, et al. Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients. Eur Neuropsychopharmacol. 2016;26:1241–7.

  10. 10.

    Wei YB, Backlund L, Wegener G, Mathe AA, Lavebratt C. Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium. Int J Neuropsychopharmacol. 2015;18:pyv002.

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The author would like to express his gratitude to Dr. Grace Thrall, whose dedicated teaching was an inspiration for this article.

Author information


  1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

    • Anthony S. Zannas


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Conflict of interest

The author declares no conflict of interest.

Corresponding author

Correspondence to Anthony S. Zannas.