Fig. 3: Timeline correlating the epithelial, vascular, and fibrotic patterns of lung injury with the duration of COVID-19 symptoms. | Modern Pathology

Fig. 3: Timeline correlating the epithelial, vascular, and fibrotic patterns of lung injury with the duration of COVID-19 symptoms.

From: A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Fig. 3

Shown are the identified histological pulmonary patterns (epithelial, vascular, and fibrotic) for 65 individual cases; each case is shown in a single column. Cases are organized chronologically in four time periods: the number of days since the onset of symptoms of COVID-19 symptoms is indicated. For the fibrotic pattern, cases shaded in light gray are cases in which fibrotic changes were likely pre-existing and were not associated with COVID-19, and cases shaded in dark gray indicate fibrotic changes. For cases indicated with an asterisk (*), the duration of the clinical course was estimated from a report with aggregated pathological findings. Shown below the timeline is the approximate occurrence of COVID-19 clinical phases, color-coded based on the three patterns of histological pulmonary changes, and the transition from L- to H-respiratory phenotypes [5]. In pre-symptomatic patients, tissue was obtained antemortem before the onset of COVID-19 symptoms. Other antemortem samples are: reference [18, 22] (cases 1 and 2), and 33; the other samples are obtained at autopsy. AFOP acute fibrinous and organizing pneumonia, NSIP nonspecific interstitial pneumonia, NA not applicable, NS not specified.

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