Fig. 4: Histologic lung findings at autopsy and SARS immunohistochemical staining in lungs from patients 1–4 with COVID-19 (SARS-CoV-2 infection). | Modern Pathology

Fig. 4: Histologic lung findings at autopsy and SARS immunohistochemical staining in lungs from patients 1–4 with COVID-19 (SARS-CoV-2 infection).

From: In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19

Fig. 4

Histologic examination of the lungs from patients 1 (a, b), 2 (c, d), 3 (e, f), and 4 (g, h) identified acute-phase diffuse alveolar damage (DAD) with extensive hyaline membrane formation (a, c, e, f, arrows). SARS immunohistochemistry (IHC) showed <5 cells with strongly positive staining per 4 mm2 in patients 1 (b, arrow, inset), 2 (d, inset), and 3 (f, inset). In patient 4, 5–50 cells with strongly positive staining were identified per 4 mm2 (h, inset).

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