Table 4 Multivariate overall survival analysis

From: Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis

Variables Tissue-obtained metastatic sites
All Lung Liver
HR 95% CI P HR 95% CI P HR 95% CI P
Histological grade in primary tumor: 3 vs. 1 and 2 2.021 1.376–2.968 <0.001 3.617 1.944–6.729 <0.001 3.115 1.564–6.201 0.001
TILs in primary tumor        1.016 1.001–1.031 0.035
Metastasis site: others vs. lung 1.197 1.083–1.323 <0.001       
Age at diagnosis of first distant metastasis     1.032 1.007–1.059 0.013    
Number of metastatic masses: multiple vs. single 1.779 1.229–2.574 0.002 1.903 1.176–3.078 0.009    
Procedure for metastasis: excision vs. biopsy     0.351 0.191–0.642 0.001    
Hormone receptor in metastasis: positive vs. negative 0.628 0.425–0.927 0.019 0.384 0.217–0.680 0.001    
  1. CI confidence interval, HR hazard ratio, TIL tumor-infiltrating lymphocyte, TLS tertiary lymphoid structure
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