Table 1 Characteristics of primary tumors according to tissue-obtained metastatic sites

From: Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis

  Tissue-obtained metastatic sites
Lung (%) Liver (%) Brain (%) Ovary (%)
Histological type
  DCIS 2 (1) 1 (1) 0 (0) 0 (0)
  IDC 158 (99) 94 (97) 52 (98) 23 (92)
  ILC 0 (0) 1 (1) 1 (2) 2 (8)
  Mucinous carcinoma 0 (0) 1 (1) 0 (0) 0 (0)
Histological grade
  1 4 (3) 1 (1) 0 (0) 0 (0)
  2 63 (39) 47 (49) 14 (26) 18 (72)
  3 70 (44) 33 (34) 35 (66) 5 (20)
   Unknown 23 (14) 16 (16) 4 (8) 2 (8)
Hormone receptor
  Negative 57 (36) 29 (30) 28 (53) 2 (8)
  Positive 90 (56) 62 (64) 23 (43) 23 (92)
  Unknown 13 (8) 6 (6) 2 (4) 0 (0)
HER2
  Negative 97 (61) 52 (54) 21 (40) 21 (84)
  Positive 41 (26) 31 (32) 29 (55) 4 (16)
  Unknown 22 (14) 14 (14) 3 (5) 0 (0)
Subtype
  HR+/HER2− 61 (38) 42 (43) 10 (19) 19 (76)
  HR+/HER2+ 22 (14) 12 (12) 13 (25) 4 (16)
  HR−/HER2+ 19 (12) 19 (20) 15 (28) 0 (0)
  TN 36 (22) 10 (10) 11 (21) 2 (8)
  Unknown 22 (14) 14 (15) 4 (7) 0 (0)
TIL (%, median) 2 3.5 5 2
TLS
  Absent 52 (32) 42 (43) 18 (34) 21 (84)
  Present 60 (38) 26 (27) 23 (43) 3 (12)
  Unknown 48 (30) 29 (30) 12 (23) 1 (4)
  1. DCIS ductal carcinoma in situ, HR hormone receptor, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, TIL tumor-infiltrating lymphocyte, TLS tertiary lymphoid structure, TN triple-negative