Review Article | Published:

Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract

Modern Pathologyvolume 31pages844861 (2018) | Download Citation

Abstract

Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal symptoms, particularly diarrhea, accompanied by non-specific or mild endoscopic abnormalities; mucosal biopsy with pathologic interpretation has a major role in the diagnosis and management of these patients. Immunocompromised individuals are at risk for all the diseases that affect those with a healthy immune system, but they are also prone to other illnesses that rarely affect immunocompetent patients. This review discusses the gastrointestinal manifestations of primary and acquired immunodeficiency, chemotherapy-related injury, and infections that show a predilection for immunocompromised patients. Key histologic features and relevant differential diagnoses are emphasized.

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Acknowledgements

We thank Laura W. Lamps, MD for her critical review of this manuscript.

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  1. Albert Einstein College of Medicine, Bronx, NY, USA

    • Nicole C. Panarelli
  2. Weill Cornell Medicine, New York, NY, USA

    • Rhonda K. Yantiss

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Correspondence to Rhonda K. Yantiss.

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https://doi.org/10.1038/s41379-018-0015-9