More than two decades trapped

Optical tweezers, crowned by Nobel Prize the first time in 1990s, have widely impacted the research landscape of atom cooling, particle manipulation/sorting, and biology. After more than two decades of steady development, it received the deserving recognition once again in 2018. Unprecedented advancements across various disciplines are believed to be spurred furthermore by this important tool of optical manipulation.

tail. His theory was confirmed experimentally by Nicolas and Hull 10 .
The force caused by light is called radiative pressure since then. It was taken for granted that the radiative force can push the particle forward due to the momentum conservation law. Ashkin 1 counter-intuitively demonstrated the gradient of the light field distribution could drag and trap the particle in the liquid with two counterpropagating laser beams. In this work, he also stated the idea of levitating atoms and molecules using resonant light with the atom transition. Ashkin and Chu 2 further demonstrated the trapping of a dielectric particle with a single strongly focused beam and extended the trapping size range to 10 μm-25 nm, which paves the most fundamental platform of optical tweezers 2 .
Chu et al. 4 demonstrated the trapping of atoms using laser beam and cooling of the atoms to extremely low temperature. The cooled atoms empower a plethora of applications, especially in high sensitivity metrology including atomic interferometry and atomic clock. In parallel, Ashkin continued to flourish the realm of optical tweezers. He managed to demonstrate the manipulation of single viruses and bacteria 5 , and singe cells alive 6 . The 1064 nm-wavelength infrared light has been employed, providing sufficiently large force with greatly reduced damage to the biology cell. It was followed by tremendous investigations and developments in biology science based on optical tweezers. Block et al. 11 studied the bead movement by single kinesin molecules with optical tweezers. Yin et al. 12 13 measured the force-extension relationships of single DNA molecules. Optical tweezers can trap micrometer-/nanometer-size items with an exerted force from 100 aN to 100 pN, right in the range of the forces within cell and macromolecular systems. Thus, optical tweezers fit perfectly for investigating and even engineering various biological process, e.g., characterization of the forces of kinesin molecules 11 , probing the viscoelastic properties 13 , and doing intracellular surgery 14 . Over the past decades, the territorial boundary of optical tweezers has also been significantly extended to various other areas, including colloid and interface science 15 , microfluidic sorting by light 16 , and even quantum science and technology based on levitated opto-mechanical system 17 . The sophistication and powerfulness of the tweezer have also been greatly boosted, e.g., nanometric optical tweezers 18 and holographic optical tweezers 19 . A schematic illustration of its historical development is shown in Fig. 1.
Although the optical tweezers have received the grand recognition of Nobel Prize twice in the past three decades, the novel physics behind the optical force still fascinate the researchers, especially when optical force meets with structured lights or materials. Novel mechanisms of optical force have been revealed. Using vortex beams, researchers reported the complex stiffness and trapping mechanism of beams with orbital angular momentum 20 . With a birefringent microparticle in vacuum, Arita et al. 21 demonstrated 5 MHz frequency of rotation using the circularly polarized beam and proposed its application in micro-gyroscope. Using beams with angular momentum, researchers managed to trap and spin the particles 22,23 . Another unprecedentedly interesting topic is the optical pulling force-the light could pull the particle toward the light source instead of pushing away. The pulling phenomena is first studied in optical solenoid beams 24 and afterwards the full framework for the theory of optical "tractor beam" is established [25][26][27] .
Apart from those exciting achievements in aforementioned areas, the optical tweezer technology rapidly expands its "contour" and synergizes with other disciplines [28][29][30] . For instance, it spurs the advancement in the ground-state cooling of macro-particles 17 , detection of non-Newtonian gravity 31 , detection of gravitational wave 32 , and Brownian Carnot engine 33 . Therefore, it is believed that the optical tweezers will continue to sail and explore the new edges, and return with more in near future.