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A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

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Fig. 1: A novel fusion RUNX1/ZNF423 in a case of relapse NUP98/NSD1+ AML displays aggressive leukemogenic potential.
Fig. 2: Additional gene fusions including RUNX1/ZNF423 cooperate with NUP98/NSD1 to promote leukemia relapse and chemoresistance.

Data availability

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. And the datasets analyzed during the current study are available in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) portal (


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This study was supported by grants from the Nation Natural Science Foundation of China (No. 82273942 to XJS), the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province (No. LR23H310001 to MDY) and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations



MDY, XJS, XJX and WXD conceived the study and analyzed data. ZBL, JYZ and XJX provided patients’ samples, collected the clinical information and performed the clinical treatment. WXD, ZMX and XYZ performed cell-based experiments. WXD, ZMX and WW performed animal studies. WXD, ZMX, SWB, YCC and ZZ performed analyses of database and sequencing data. JC, QJH and BY helped conceive the experiments. MDY, XJS and WXD wrote the paper.

Corresponding authors

Correspondence to Xuejing Shao, Xiaojun Xu or Meidan Ying.

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The authors declare no competing interests.

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Approval from the Institutional Research Ethics Committee of the hospital were obtained before the use of these clinical materials for research purposes. The Animal Research Committee at Zhejiang University approved all animal studies and animal care was provided in accordance with the institutional guidelines.

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Du, W., Xia, Z., Luo, Z. et al. A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML. Leukemia 37, 2286–2291 (2023).

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