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ACUTE MYELOID LEUKEMIA

A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

Leukemia volume 37, pages 2286–2291 (2023)Cite this article

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Fig. 1: A novel fusion RUNX1/ZNF423 in a case of relapse NUP98/NSD1+ AML displays aggressive leukemogenic potential.
Fig. 2: Additional gene fusions including RUNX1/ZNF423 cooperate with NUP98/NSD1 to promote leukemia relapse and chemoresistance.

Data availability

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. And the datasets analyzed during the current study are available in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) portal (https://ocg.cancer.gov/programs/target).

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Funding

This study was supported by grants from the Nation Natural Science Foundation of China (No. 82273942 to XJS), the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province (No. LR23H310001 to MDY) and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China

    Wenxin Du, Zhimei Xia, Shaowei Bing, Wei Wang, Xingya Zhang, Ji Cao, Bo Yang, Qiaojun He, Xuejing Shao & Meidan Ying

  2. Division of Hematology-Oncology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 310052, Hangzhou, China

    Zebin Luo, Jingying Zhang, Xiaojun Xu & Meidan Ying

  3. Innovation Institute for Artificial Intelligence in Medicine, Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences and Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, 310018, Hangzhou, China

    Yichang Chen & Zhan Zhou

  4. Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, 310000, Hangzhou, China

    Ji Cao, Bo Yang, Qiaojun He & Meidan Ying

  5. Cancer Center, Zhejiang University, 310058, Hangzhou, China

    Qiaojun He & Meidan Ying

Authors
  1. Wenxin Du
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  2. Zhimei Xia
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  3. Zebin Luo
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  4. Yichang Chen
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  6. Wei Wang
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  7. Xingya Zhang
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  8. Zhan Zhou
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  10. Ji Cao
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  11. Bo Yang
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  12. Qiaojun He
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  13. Xuejing Shao
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  14. Xiaojun Xu
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  15. Meidan Ying
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Contributions

MDY, XJS, XJX and WXD conceived the study and analyzed data. ZBL, JYZ and XJX provided patients’ samples, collected the clinical information and performed the clinical treatment. WXD, ZMX and XYZ performed cell-based experiments. WXD, ZMX and WW performed animal studies. WXD, ZMX, SWB, YCC and ZZ performed analyses of database and sequencing data. JC, QJH and BY helped conceive the experiments. MDY, XJS and WXD wrote the paper.

Corresponding authors

Correspondence to Xuejing Shao, Xiaojun Xu or Meidan Ying.

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The authors declare no competing interests.

Ethics approval and consent to participate

Approval from the Institutional Research Ethics Committee of the hospital were obtained before the use of these clinical materials for research purposes. The Animal Research Committee at Zhejiang University approved all animal studies and animal care was provided in accordance with the institutional guidelines.

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Du, W., Xia, Z., Luo, Z. et al. A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML. Leukemia 37, 2286–2291 (2023). https://doi.org/10.1038/s41375-023-02024-6

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