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EPIDEMIOLOGY

Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank

Leukemia volume 37, pages 2306–2308 (2023)Cite this article

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Fig. 1: Association between CHIP and incident infections is partly mediated by transformation to hematologic cancers.

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Author information

Authors and Affiliations

  1. Department of Medicine, Queen’s University, Kingston, ON, Canada

    Caitlyn Vlasschaert

  2. Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA

    Elvis Akwo & Cassianne Robinson-Cohen

  3. Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON, Canada

    Elina K. Cook & Michael J. Rauh

  4. Department of Medicine, McMaster University, Hamilton, ON, Canada

    Matthew B. Lanktree

  5. Population Health Research Institute (PHRI), Hamilton, ON, Canada

    Matthew B. Lanktree

  6. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada

    Matthew B. Lanktree

  7. Department of Medicine, Division of Genomic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Alexander G. Bick

Authors
  1. Caitlyn Vlasschaert
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  2. Elvis Akwo
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  3. Cassianne Robinson-Cohen
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  4. Elina K. Cook
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  5. Matthew B. Lanktree
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  6. Michael J. Rauh
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  7. Alexander G. Bick
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Contributions

CV, EA, and AJB designed the study. CV conducted the analyses and wrote the manuscript. EA, EKC, CR-C, MBL, MJR, and AJB provided critical feedback on the results and manuscript draft.

Corresponding author

Correspondence to Alexander G. Bick.

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Competing interests

AGB is a co-founder, equity holder, and on the scientific advisory board of TenSixteen Bio. MBL has received speaking and advisory board fees from Bayer, Otsuka, Reata and Sanofi. All other authors declare no conflicts of interest.

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Vlasschaert, C., Akwo, E., Robinson-Cohen, C. et al. Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank. Leukemia 37, 2306–2308 (2023). https://doi.org/10.1038/s41375-023-02023-7

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  • DOI: https://doi.org/10.1038/s41375-023-02023-7

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