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The datasets generated during and/or analyzed during the current study are available in the Gene Expression Omnibus (GEO) repository, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219043.
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The work was supported by the Intramural Research Programs of the National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, and Natioal Cancer Institute, NIH. The authors would like to thank Zhi Liu and Jim Mullikin for preliminary STREAM testing, Erika Kwon, Erica Bresciani and Elisabeth Heuston for insightful discussion, as well as Luigi Alvarado (now at 10X Genomics) and the LaRochelle lab at NHLBI (NIH) for critical pilot drop-seq experiments that led to this study. This work used the computational resources of the NIH highperformance computing Biowulf cluster (https://hpc.nih.gov).
The authors declare no competing interests.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Diemer, J.L., Yu, K., Kelly, M. et al. Characterization of leukemia progression in the Cbfb-MYH11 knockin mice by single cell RNA sequencing. Leukemia 37, 1549–1553 (2023). https://doi.org/10.1038/s41375-023-01926-9