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Molecular mechanisms underlying transformation of large granular lymphocytic leukemia to high-grade T-cell lymphoma

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Fig. 1: Histological and biological overview of the two clinical cases.
Fig. 2: Molecular whole exome sequencing results and clonal hierarchy hypothesis.

Data availability

The processed somatic mutations and copy number alterations are provided in the Supplementary Datasets. Additional clinical metadata and fastq.gz files are available on request at


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The authors wish to thank the biological resource center (Centre de Ressource Biologique-Santé; Rennes, France BB-0033-0006). This project was funded in part by the Hematology Laboratory at Rennes University Medical Center and the Association pour le Développement de l’Hématologie Oncologie (ADHO).

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Authors and Affiliations



CP, TL and TM designed the research and wrote the paper; FLG and PG reviewed the histology data; MF, AM and RH managed the clinical cases; MR provided the flow cytometry data; CP, MLB and TF analyzed the molecular data, all authors critically reviewed the paper.

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Correspondence to Thierry Lamy.

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Pastoret, C., Llamas-Gutierrez, F., Fouchard, M. et al. Molecular mechanisms underlying transformation of large granular lymphocytic leukemia to high-grade T-cell lymphoma. Leukemia 37, 1567–1571 (2023).

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