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Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

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Fig. 1: Pattern of somatic mutations in HCV-associated B-NHL.
Fig. 2: Landscape of somatic alterations in HCV-associated B-NHL.

Data availability

WES data have been deposited in the European Genome-phenome Archive (EGA) under accession EGAS00001006860.


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This work was supported by a grant from ANRS (Agence Nationale de Recherches sur le Sida et les Hépatites Virales) (reference number: ECTZ22779) and in part by an ERA-NET TRANSCAN-2/French National Cancer Institute grant (acronym NOVEL). We are grateful to the patients for their participation. We would also like to thank all the staff from the Imagine genomic core facility and the Cytometry facility CyPS (Plateforme de cytométrie CyPS, Pitié-Salpêtrière, Sorbonne Université, Paris) for their advice and excellent technical support. We acknowledge all the participating tumor biobanks for managing and providing biological samples: Saint-Louis Hospital, Centre de Ressources Biologiques-Cancer de Toulouse, Centre de Ressources Biologiques de Limoges (CRBioLim), Centre de Ressources Biologiques de la Tumorothèque de Rouen, Lyon Sud Hospital, Necker-Enfants malades Hospital, Pitié-Salpêtrière Hospital.

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LC, OH and FD designed the study; MA, MD, FD and LC interpreted the data; MD performed DNA extraction from tumor samples; BT and CL performed the bioinformatics and biostatistics analyses; MV performed the Sanger sequencing; MP conducted the NGS experiments; BH-C was responsible of the cell-sorting experiments; J-MM and CB collected the clinical data; DC, FC, VM, CL, AT-G and DD provided tumor samples and performed histopathological reviews; CB, EB and OH participated in critical revision of the manuscript; MA, MD, FD and LC wrote the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Lucile Couronné.

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Armand, M., Degaud, M., Tesson, B. et al. Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing. Leukemia (2023).

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