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MCL1 as a therapeutic vulnerability in Burkitt lymphoma

Leukemia (2023)Cite this article

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Fig. 1: MCL-1 is constitutively over-expressed and a key molecular therapeutic vulnerability for Burkitt lymphoma (BL) and a subset of large B-cell lymphomas.
Fig. 2: BCL-XL functions as a switch to govern MCL-1 inhibitor (MCL-1i) resistance ex vivo and in vivo.

Data availability

The datasets analyzed during the current study are available in the Gene Expression Omnibus repository under access numbers GSE10172 and GSE4475.

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Funding

This work was supported by funds from the Florida State Live Like Bella Pediatric Cancer Research Initiative.

Author information

Author notes

  1. These authors contributed equally: Ren Yuan, Michelle Y. Wang.

  2. These authors jointly supervised this work: Xiaohong Zhao, Jianguo Tao.

Authors and Affiliations

  1. Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA

    Ren Yuan & Xiaohong Zhao

  2. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA

    Michelle Y. Wang

  3. Department of Pathology, University of Nebraska Medical Center, Omaha, NE, 68198, USA

    Chengfeng Bi

  4. Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, 22903, USA

    Jianguo Tao

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  1. Ren Yuan
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  4. Xiaohong Zhao
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Contributions

RY was responsible for generating all CRISPR/cas9 cells and protein overexpressing cells, performing western blot experiments, and interpreting data. MYW was responsible for performing and analyzing image based cell viability assays in cell lines and patient samples, other cell viability assays, editing the manuscript. CB was responsible for providing patient samples and providing feedback on the study. XZ was responsible for study conception and design, performing cell viability experiments, the in vivo study, performing the analysis on the GEO patient datasets and editing the manuscript. JT was responsible for conception and design of the study, analyzing and interpreting all data, writing and reviewing the manuscript, and providing administrative, technical, and material support.

Corresponding author

Correspondence to Jianguo Tao.

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Yuan, R., Wang, M.Y., Bi, C. et al. MCL1 as a therapeutic vulnerability in Burkitt lymphoma. Leukemia (2023). https://doi.org/10.1038/s41375-023-01827-x

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