Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Juvenile myelomonocytic leukemia; moving forward

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed in this study. This is a correspondence letter.


  1. Niemeyer CM, Rudelius M, Shimamura A, Flotho C, Hasle H, Stieglitz E, et al. Classification of rare pediatric myeloid neoplasia-Quo vadis? Leukemia. 2022;36:2947–8.

    Article  PubMed  Google Scholar 

  2. Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022;36:1703–19.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, et al. International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140:1200–28.

    Article  CAS  PubMed  Google Scholar 

  4. Alaggio R, Carneiro F, Chan JKC, Cheung ANY, Cree IA, Denton E, et al. (Eds), WHO Classification of Tumours: Paediatric tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 2022/11/22]. (WHO Classification of Tumours series, 5th ed.; vol. 7). Available from:

  5. Strullu M, Caye A, Cassinat B, Fenneteau O, Touzot F, Blauwblomme T, et al. In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia. Leukemia. 2013;27:2404–7.

    Article  CAS  PubMed  Google Scholar 

  6. Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds): WHO classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press: Lyon 2001.

  7. Swerldow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. (Eds): WHO classification of tumours of haematopoietic and lymphoid tissues, IARC: Lyon 2008.

  8. Swerldow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. (Eds): WHO classification of tumours of haematopoietic and lymphoid tissue (revised 4th edition), IARC: Lyon 2017.

  9. Kanayama T, Imamura T, Kawabe Y, Osone S, Tahara J, Iwasaki F, et al. KMT2A-rearranged infantile acute myeloid leukemia masquerading as juvenile myelomonocytic leukemia. Int J Hematol. 2018;108:665–9.

    Article  CAS  PubMed  Google Scholar 

  10. Schwatrz JR, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, et al. The genomic landscape of pediatric myelodysplastic syndromes. Nat Commun. 2017;8:1557.

    Article  Google Scholar 

  11. Hecht A, Meyer JA, Behnert A, Wong E, Chehab F, Olshen A, et al. Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia. Haematologica 2022;107:178–86.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations



MTE wrote the first draft, HC, RDV, MMP, ES, and JDK reviewed the manuscript and provided critical edits and modifications. All authors read and approved the manuscript.

Corresponding author

Correspondence to M. Tarek Elghetany.

Ethics declarations

Competing interests

MMP has received research funding from Kura Oncology and StemLine Pharmaceuticals and has served on the advisory board for CTI Pharmaceuticals. The other authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Elghetany, M.T., Cavé, H., De Vito, R. et al. Juvenile myelomonocytic leukemia; moving forward. Leukemia 37, 720–722 (2023).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links