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ACUTE MYELOID LEUKEMIA

Prognostic implications of mono-hit and multi-hit TP53 alterations in patients with acute myeloid leukemia and higher risk myelodysplastic syndromes treated with azacitidine-based therapy

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Fig. 1: Overall survival by TP53 mutation status.

Data availability

Original data are available from the corresponding author at request.

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Acknowledgements

AMZ is a Leukemia and Lymphoma Society Scholar in Clinical Research.

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Authors and Affiliations

Authors

Contributions

JPB, BF, and AMZ conceptualized the study. BF, VH, ET, and TH performed data analyses. JPB and AMZ wrote the initial manuscript draft. All authors interpreted data and contributed to subsequent drafts of the manuscript.

Corresponding author

Correspondence to Amer M. Zeidan.

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Competing interests

AMZ received research funding (institutional) from Celgene/BMS, Abbvie, Astex, Pfizer, Medimmune/AstraZeneca, Boehringer-Ingelheim, Cardiff oncology, Incyte, Takeda, Novartis, Aprea, and ADC Therapeutics. AMZ participated in advisory boards, and/or had a consultancy with and received honoraria from AbbVie, Otsuka, Pfizer, Celgene/BMS, Jazz, Incyte, Agios, Boehringer-Ingelheim, Novartis, Acceleron, Astellas, Daiichi Sankyo, Cardinal Health, Taiho, Seattle Genetics, BeyondSpring, Cardiff Oncology, Takeda, Ionis, Amgen, Janssen, Epizyme, Syndax, Gilead, Kura, Chiesi, ALX Oncology, BioCryst, Notable, Orum, and Tyme. AMZ served on clinical trial committees for Novartis, Abbvie, Gilead, BioCryst, Abbvie, ALX Oncology, Geron and Celgene/BMS. RMS participated in advisory boards, and/or had a consultancy with and received honoraria from Bristol Myers Squibb and Gilead Sciences, Inc; divested equity interest in Curis Oncology. IB, ET, BAF, VEH, and SR are employees of Celgene, a Bristol Myers Squibb company, and may be shareholders. SH has received research funding received honoraria from FORMA Therapeutics. TH is the owner of Munich Leukemia Laboratory. All other authors have no relevant conflicts of interest to declare.

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Zeidan, A.M., Bewersdorf, J.P., Hasle, V. et al. Prognostic implications of mono-hit and multi-hit TP53 alterations in patients with acute myeloid leukemia and higher risk myelodysplastic syndromes treated with azacitidine-based therapy. Leukemia 37, 240–243 (2023). https://doi.org/10.1038/s41375-022-01766-z

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