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STEM CELL BIOLOGY

REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses

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Fig. 1: REDD1 deficiency induces a partial loss of HSC self-renewal potential and leads to HSC exhaustion upon genotoxic stress.
Fig. 2: The increased ROS levels after irradiation in Redd1−/− mice are responsible for the defects of HSC response to stress in absence of REDD1.

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Acknowledgements

This work was supported by the Radiobiology Program of the French Alternative Energies and Atomic Energy Commission (CEA) and the Ligue régionale contre le cancer (comité 92) to M-LA and by grants from INSERM and by the Ligue Nationale contre le Cancer (LNCC). EH is a fellow of LNCC and RK, of Canceropôle Ile-de-France. We thank all members of Pflumio’ lab in particular Dr Haddad and Dr Calvo for their scientific advices and their support and Dr Gallouet (CEA-IDMIT) for her precious help. We also thank Dr Guitart from Bordeaux University for her help. We are grateful to Dr Roméo, Dr Lewandowski and Dr Carles for constant support and interest.

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VB, M-LA, EH and ND performed experiments with the help of PC, SD and RK. M-LA designed and analyzed data. AJ, GR and PA corrected the manuscript. FP and M-LA wrote the manuscript.

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Correspondence to Marie-Laure Arcangeli.

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Barroca, V., Henry, E., Dechamps, N. et al. REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses. Leukemia (2022). https://doi.org/10.1038/s41375-022-01609-x

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