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ACUTE LYMPHOBLASTIC LEUKEMIA

A simple algorithm with one flow cytometric MRD measurement identifies more than 40% of children with ALL who can be cured with low-intensity therapy. The ALL-MB 2008 trial results

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Fig. 1: Event-free survival (EFS, solid lines) and cumulative incidence of relapse (CIR, dashed lines) according to MFC-MRD values.

Data availability

For original data, please contact uralcytometry@gmail.com.

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Acknowledgements

The authors thank all doctors, nurses and laboratory personel in participating institutions, who were involved in patients diagnostics, management and monitoring. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Contributions

AP – concept and design of the study, MFC-MRD data, data analysis and interpretation, writing the paper. GH – concept and design of the study, data analysis and interpretation, writing the paper. JR – database handling, data analysis and interpretation, writing the paper. OB – database handling, statistics. MB – MFC-MRD data. TV – MFC-MRD data. EB – MFC-MRD data. LM – MFC-MRD data. GT – data analysis and interpretation. MF – MFC-MRD data. SL – database handling, data analysis. LZh – database handling, data analysis. NM – patients data. DL – patients data. OKh – patients data. OS – patients data. ES – patients data. NP – patients data. GN – concept and design of the study, general supervising, writing the paper. LF – concept and design of the study, general supervising, writing the paper. OA – concept and design of the study, general supervising, writing the paper. AK – concept and design of the study, data analysis and interpretation, general supervising, writing the paper. AP and GH contributed equally to this work. All authors have read and approved the final version of manuscript.

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Correspondence to Alexander Popov.

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Popov, A., Henze, G., Roumiantseva, J. et al. A simple algorithm with one flow cytometric MRD measurement identifies more than 40% of children with ALL who can be cured with low-intensity therapy. The ALL-MB 2008 trial results. Leukemia 36, 1382–1385 (2022). https://doi.org/10.1038/s41375-022-01542-z

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