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Multiple myeloma, gammopathies

External validation of the FIRST trial’s simplified frailty score in a population-based cohort

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References

  1. 1.

    Palumbo A, Bringhen S, Mateos MV, Larocca A, Facon T, Kumar SK, et al. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report. Blood. 2015;125:2068–74. 26

    Article  CAS  Google Scholar 

  2. 2.

    Milani P, Vincent Rajkumar S, Merlini G, Kumar S, Gertz MA, Palladini G, et al. N-terminal fragment of the type-B natriuretic peptide (NT-proBNP) contributes to a simple new frailty score in patients with newly diagnosed multiple myeloma. Am J Hematol. 2016;91:1129–34.

    Article  CAS  Google Scholar 

  3. 3.

    Engelhardt M, Domm AS, Dold SM, Ihorst G, Reinhardt H, Zober A, et al. A concise revised Myeloma Comorbidity Index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients. Haematologica. 2017;102:910–21.

    Article  Google Scholar 

  4. 4.

    Mian H, Brouwers M, Kouroukis CT, Wildes TM. Comparison of frailty scores in newly diagnosed patients with multiple myeloma: a review. J Frailty Aging. 2019;8:215–21.

    PubMed  CAS  Google Scholar 

  5. 5.

    Facon T, Dimopoulos MA, Meuleman N, Belch A, Mohty M, Chen WM, et al. A simplified frailty scale predicts outcomes in transplant-ineligible patients with newly diagnosed multiple myeloma treated in the FIRST (MM-020) trial. Leukemia. 2020;34:224–33.

    Article  Google Scholar 

  6. 6.

    Stege CAM, van der Holt B, Dinmohamed AG, Sonneveld P, Levin M-D, van de Donk NWCJ, et al. Validation of the FIRST simplified frailty scale using the ECOG performance status instead of patient-reported activities. Leukemia. 2020;34:1964–6. 2020/07/01

    Article  Google Scholar 

  7. 7.

    Duma N, Azam T, Riaz IB, Gonzalez-Velez M, Ailawadhi S, Go R. Representation of minorities and elderly patients in multiple myeloma clinical trials. Oncologist. 2018;23:1076–8.

    Article  Google Scholar 

  8. 8.

    Anderson F, Downing GM, Hill J, Casorso L, Lerch N. Palliative performance scale (PPS): a new tool. J Palliat Care. 1996;12:5–11. Spring

    Article  CAS  Google Scholar 

  9. 9.

    Popovic G, Harhara T, Pope A, Al-Awamer A, Banerjee S, Bryson J, et al. Patient-reported functional status in outpatients with advanced cancer: correlation with physician-reported scores and survival. J Pain Symptom Manag. 2018;55:1500–8.

    Article  Google Scholar 

  10. 10.

    Martin L, Watanabe S, Fainsinger R, Lau F, Ghosh S, Quan H, et al. Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction. J Clin Oncol. 2010;28:4376–83. 1

    Article  Google Scholar 

  11. 11.

    Chari A, Romanus D, Palumbo A, Blazer M, Farrelly E, Raju A, et al. Randomized clinical trial representativeness and outcomes in real-world patients: comparison of 6 hallmark randomized clinical trials of relapsed/refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 2020;20(Jan):8–17.e16.

    Article  Google Scholar 

  12. 12.

    Kumar V, Ailawadhi M, Dutta N, Abdulazeez M, Aggarwal CS, Quintero G, et al. Trends in early mortality from multiple myeloma: a population-based analysis. Clin Lymphoma Myeloma Leuk. 2020. https://doi.org/10.1016/j.clml.2020.12.023.

  13. 13.

    Cairns D, Pawlyn C, Royle K-L, Best P, Bird J, Bowcock S, et al. Frailty-adjusted therapy in transplant non-eligible patients with newly diagnosed multiple myeloma (FiTNEss): a UK myeloma research alliance study, myeloma XIV. Blood. 2019;134:3153–3153.

    Article  Google Scholar 

  14. 14.

    Knauf W, Aldaoud A, Hutzschenreuter U, Klausmann M, Dille S, Wetzel N, et al. Survival of non-transplant patients with multiple myeloma in routine care differs from that in clinical trials—data from the prospective German Tumour Registry Lymphatic Neoplasms. Ann Hematol. 2018;97:2437–45. 2018/12/01

    Article  Google Scholar 

  15. 15.

    Repetto L, Fratino L, Audisio RA, Venturino A, Gianni W, Vercelli M, et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol. 2002;20(Jan):494–502. 15

    Article  Google Scholar 

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Acknowledgements

HM is supported in part by the HHS Research Early Career Award from Hamilton Health Sciences Foundation. This investigation was supported by funding from Myeloma Canada. This study was supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and/or information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions and statements expressed in the material are those of the authors, and not necessarily those of CIHI. We acknowledge Cancer Care Ontario for access to the Ontario Cancer Registry (OCR), Cancer Activity Level Reporting (ALR), Symptom Management Database (ESAS) and The New Drug Funding Program (NDFP). We thank IQVIA Solutions Canada Inc. for use of their Drug Information Database. SG is supported in part by the Walter B Frommeyer Fellowship in Investigative Medicine, Department of Medicine, University of Alabama at Birmingham

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Correspondence to Hira S. Mian.

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HS: Consultancy/Honoraria fees from Celgene, Takeda, Janssen, Amgen, Sanofi, SG: Reports research funding from CareVive, PackHealth, Sanofi and Oncopeptides. Honoraria from Carevive, Janssen, GP: Has a close family member who is employed by Roche Canada, and who owns Roche Canada stock. Consultancy fees from Astra-Zeneca. Honorarium from Takeda, TW: reports Research funding from Janssen and is a consultant for Carevive Systems and Seattle Genetics, AB, BS, AM, HS: None.

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Mian, H.S., Giri, S., Wildes, T.M. et al. External validation of the FIRST trial’s simplified frailty score in a population-based cohort. Leukemia (2021). https://doi.org/10.1038/s41375-021-01247-9

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