Fig. 2: CD4+ or CD8+ specific somatic mutations in JAK-STAT pathway genes in AA patients. | Leukemia

Fig. 2: CD4+ or CD8+ specific somatic mutations in JAK-STAT pathway genes in AA patients.

From: Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

Fig. 2

A Mean target coverage of each sample is presented in the top panel. Variants on homopolymer regions are marked with white dots. B Mutations marked on JAK-STAT signaling pathway based on KEGG database [38], complemented with closely related MAPK-Erk and PI3K-Akt-mTOR pathways. Patients with homopolymer region variants are colored with blue. Patients with pathogenic-predicted variants are marked with an asterisk (*). C Mutational signatures from pooled CD4+ and CD8+ T-cell somatic variants from each patient group.

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