A Mean target coverage of each sample is presented in the top panel. Variants on homopolymer regions are marked with white dots. B Mutations marked on JAK-STAT signaling pathway based on KEGG database , complemented with closely related MAPK-Erk and PI3K-Akt-mTOR pathways. Patients with homopolymer region variants are colored with blue. Patients with pathogenic-predicted variants are marked with an asterisk (*). C Mutational signatures from pooled CD4+ and CD8+ T-cell somatic variants from each patient group.