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STEM CELL TRANSPLANTATION

Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation

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Fig. 1: HSPC mobilization involves thrombin/PAR1/NO axis activity.
Fig. 2: Thrombin inhibition reduces EPCR shedding, facilitating HSPC homing and engraftment.

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Acknowledgements

This work was partially supported by the Israel Science Foundation (ISF), a joint grant from the Israel Science Foundation (ISF) and the National Natural Science Foundation of China (NSFC), Minerva Foundation and the Federal German Ministry for Education and Research, Steven B. Rubenstein Research Fund, Weizmann Stem Cell Institute, The WIS Moross Integrated Cancer Center, Asher Pertman and Wayne Pertman, and the Estate of David Levinson.

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NN and OK reviewed literature, designed and conducted experiments, analyzed results, and wrote the paper. SGC, LAOM, FA, MB, EKM, MH, PC, and SB designed and performed experiments, analyzed data, and reviewed the manuscript. WR participated in designing experiments and reviewed the manuscript. TL reviewed literature, designed the study concept, guided the research, and wrote the paper.

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Correspondence to Tsvee Lapidot or Orit Kollet.

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Nevo, N., Ordonez-Moreno, LA., Gur-Cohen, S. et al. Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation. Leukemia (2021). https://doi.org/10.1038/s41375-021-01194-5

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