Myelodysplastic syndrome

Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations

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Fig. 1: Characteristics, mutational associations and prognostic implications of clonal events in SF3B1 mutant myeloid neoplasms.
Fig. 2: The clonal trajectories of SF3B1 mutations.

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Acknowledgements

We thank the following sources of funding: Aplastic Anemia and MDS International Foundation Research Grant (VV and JPM), Vera and Joseph Dresner Foundation-MDS Research Fund (VV), VeloSano Pilot Award (VV), NIH/NHLBI R35HL135795 (JPM), R01HL132071 (JPM), The Henry and Marilyn Taub Foundation (JPM). We thank the team of Mission Bio for technical expertise on single cell-DNA sequencing and The Cancer Genome Atlas (TCGA), The BEAT AML Master Trial and The German-Austrian Study Group for data accessibility.

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Contribution: HA collected, analyzed and interpreted the data, designed the tables and figures, and wrote the manuscript; CMK, AD developed DNA-sequencing methodologies, analyzed single cell-DNA sequencing, and edited the manuscript; VA; CG, SP, MZ, SK, collected the data and edited the manuscript; HJR collected clinical info and provided critical review to the manuscript; YS, MAS, HEC provided patients and important insights to the manuscript preparation; JPM provided patients, laboratory space and facilities, granted a collection of clinical charts and molecular annotated databases, sponsored the DNA sequencing studies, and edited the manuscript; VV conceived the idea, designed the study, supervised the work, interpreted and analyzed the data and content, and wrote the manuscript.

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Correspondence to Valeria Visconte.

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Awada, H., Kerr, C.M., Durmaz, A. et al. Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations. Leukemia (2021). https://doi.org/10.1038/s41375-021-01176-7

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