MULTIPLE MYELOMA, GAMMOPATHIES

Role of MBD3-SOX2 axis in residual myeloma following pomalidomide

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Fig. 1: Enhanced clonogenic potential and growth of pomalidomide-residual disease is SOX2 dependent.
Fig. 2: MBD3 mediated SOX2 enrichment of human MM cells in Pom exposed residual MM cells.

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Acknowledgements

MVD is supported in part by funds from NCI R35 CA197603, Specialized Center for Research and translational research program of Leukemia and Lymphoma Society and the Multiple Myeloma Research Foundation (MMRF). Authors would like to thank patients and clinical colleagues at Yale, and Zifeng Mai, Lin Zhang, Dr. Mehmet H Kocoglu, Carla Weibel, Jon Alderman, Grzegorz Wylezinski, Dr. Roni Nowarski for their support.

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Affiliations

  1. Department of Medicine, Yale University, New Haven, CT, USA

    Rakesh Verma

  2. Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, USA

    Andrew R. Branagan

  3. Department of Pathology, Yale University, New Haven, CT, USA

    Mina L. Xu

  4. Department of Laboratory Medicine, Yale University, New Haven, CT, USA

    Mina L. Xu

  5. Department of Immunobiology, Yale University, New Haven, CT, USA

    Richard A. Flavell

  6. Howard Hughes Medical Institute, Yale University, New Haven, CT, USA

    Richard A. Flavell

  7. Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University, Atlanta, GA, USA

    Kavita M. Dhodapkar

  8. Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Kavita M. Dhodapkar & Madhav V. Dhodapkar

  9. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA

    Madhav V. Dhodapkar

Authors
  1. Rakesh Verma
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  2. Andrew R. Branagan
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  3. Mina L. Xu
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  4. Richard A. Flavell
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  5. Kavita M. Dhodapkar
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  6. Madhav V. Dhodapkar
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Contributions

RV designed and performed experiments and wrote the manuscript. AB and KD performed clinical research and provided access to specimens. MLX provided help with immunohistochemical analyses. RAF provided access to mice used in the study. MVD provided oversight for the project and wrote manuscript. All authors contributed to interpretation of data and approved the final manuscript.

Corresponding authors

Correspondence to Rakesh Verma or Madhav V. Dhodapkar.

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Verma, R., Branagan, A.R., Xu, M.L. et al. Role of MBD3-SOX2 axis in residual myeloma following pomalidomide. Leukemia (2021). https://doi.org/10.1038/s41375-021-01145-0

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