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MYELODYSPLASTIC SYNDROME

Germline variants drive myelodysplastic syndrome in young adults

Leukemia volume 35, pages 2439–2444 (2021)Cite this article

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Fig. 1: Incidence and variation in age of onset by causal gene.

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Acknowledgements

The authors would like to gratefully acknowledge all of the individuals who participated in this study and their physicians for submitting the clinical samples. We would also like to thank Michelle Le Beau and Ludmila Hill from the Cancer Cytogenetics Laboratory at The University of Chicago for providing viably frozen bone marrow samples. This study was supported by the Cancer Research Foundation and the Taub Foundation (L.A.G.), the intramural ‘Baustein’ program for Junior Scientists of the Medical Faculty of Ulm University, Ulm, Germany (S.F.), and the German Bundesministerium für Bildung und Forschung ‘MyPred’ (01GM1911B) (B.S., G.G.) and ‘ADDRess’ (01GM1909A) (G.G.) and the Cancer Society of Finland, the Children’s Cancer Foundation Väre, and the Sigrid Juselius Foundation (M.H., O.K., U.W-K.). In addition, the NIH supported this work through: P30CA016056 (use of Roswell Park Comprehensive Cancer Center’s Hematologic Procurement Shared Resource, E.W.), R03HL145253 (J.E.C.), R35CA197458 and R24DK099808 (M-C.K., T.W., S.G., M.L.). We would also like to acknowledge the input of Linda Lutgen-Dunckley, Brandon Martens, and Joseph Moberg from the Roswell Park Hematologic Procurement Shared Resource (CIC 98-05) for providing samples supported by the Cancer Center Support Grant at Roswell Park (2P30CA016056-42). M-C.K. is an American Cancer Society Professor.

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Authors and Affiliations

  1. Department of Medicine, Section of Hematology/Oncology, The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA

    Simone Feurstein & Lucy A. Godley

  2. Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, The University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Jane E. Churpek

  3. Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA

    Tom Walsh

  4. Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA

    Sioban Keel

  5. Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Marja Hakkarainen, Outi Kilpivaara & Ulla Wartiovaara-Kautto

  6. Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki, Finland

    Marja Hakkarainen & Ulla Wartiovaara-Kautto

  7. Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany

    Thomas Schroeder, Ulrich Germing & Stefanie Geyh

  8. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

    Michael Heuser & Felicitas Thol

  9. Munich Leukemia Laboratory, Munich, Germany

    Christian Pohlkamp & Torsten Haferlach

  10. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Juehua Gao

  11. Division of Hematology and Hematological Malignancies, University of Calgary, Calgary, AB, Canada

    Carolyn Owen

  12. Department of Human Genetics, Hannover Medical School, Hannover, Germany

    Gudrun Goehring & Brigitte Schlegelberger

  13. Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Medicine, Frankfurt, Germany

    Divij Verma & Daniela S. Krause

  14. Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA

    Divij Verma

  15. Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA

    Guimin Gao

  16. Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Tara Cronin, Eunice S. Wang & Elizabeth A. Griffiths

  17. Department of Genome Sciences, University of Washington, Seattle, WA, USA

    Suleyman Gulsuner, Ming Lee & Mary-Claire King

  18. Department of Laboratory Medicine, University of Washington, Seattle, WA, USA

    Colin C. Pritchard

  19. Department of Human Genetics, The University of Chicago, Chicago, IL, USA

    Hari Prasanna Subramanian, Daniela del Gaudio & Soma Das

  20. Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX, USA

    Zejuan Li

  21. Department of Medical and Clinical Genetics/Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Outi Kilpivaara

  22. Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

    Konstanze Döhner & Hartmut Döhner

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  35. Lucy A. Godley
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Corresponding author

Correspondence to Lucy A. Godley.

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Conflict of interest

We declare the following conflicts of interest: TW consults for Color Genomics. TH is part owner of the Munich Leukemia Laboratory. EAG has received honoraria/advisory board payments from Alexion Pharmaceuticals, Celgene/BMS, AbbVie, and Novartis. EAG has also received institutional research funding from Genentech Inc., Appelis pharmaceuticals, Celldex Therapeutics, and Celgene/BMS. CO has received honoraria/advisory board payments from AbbVie, AstraZeneca, Janssen, Roche, and Novartis. LAG and JEC have received honoraria from UptoDate, Inc. LAG has received advisory board payments from Invitae, Inc.

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Feurstein, S., Churpek, J.E., Walsh, T. et al. Germline variants drive myelodysplastic syndrome in young adults. Leukemia 35, 2439–2444 (2021). https://doi.org/10.1038/s41375-021-01137-0

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