Acute myeloid leukemia

Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: TP73 and TP53 Mutation lollipop plots.
Fig. 2: Kaplan-Meier survival curves.


  1. 1.

    Vousden KH, Lu X. Live or let die: the cell’s response to p53. Nat Rev Cancer. 2002;2:594–604.

    CAS  Article  Google Scholar 

  2. 2.

    Candi E, Agostini M, Melino G, Bernassola F. How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat. 2014;35:702–14.

    CAS  Article  Google Scholar 

  3. 3.

    Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2:a001008.

    Article  Google Scholar 

  4. 4.

    Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Fu B, Tang G, et al. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo disease. Leuk Res. 2015;39:348–54.

    CAS  Article  Google Scholar 

  5. 5.

    Rücker FG, Schlenk RF, Bullinger L, Kayser S, Teleanu V, Kett H, et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2012;119:2114–21.

    Article  Google Scholar 

  6. 6.

    The Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368:2059–74.

  7. 7.

    Eisfeld A-K, Mrózek K, Kohlschmidt J, Nicolet D, Orwick S, Walker CJ, et al. The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia. Leukemia. 2017;31:2211–8.

    CAS  Article  Google Scholar 

  8. 8.

    Mrózek K, Eisfeld A-K, Kohlschmidt J, Carroll AJ, Walker CJ, Nicolet D, et al. Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically. Leukemia. 2019;33:1620–34.

    Article  Google Scholar 

  9. 9.

    Stengel A, Kern W, Haferlach T, Meggendorfer M, Fasan A, Haferlach C. The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS, and CLL: an analysis of 3307 cases. Leukemia. 2017;31:705–11.

    CAS  Article  Google Scholar 

  10. 10.

    Quek L, Ferguson P, Metzner M, Ahmed I, Kennedy A, Garnett C, et al. Mutational analysis of disease relapse in patients in patients allografted for acute myeloid leukemia. Blood Adv. 2016;1:193–204.

    CAS  Article  Google Scholar 

  11. 11.

    Wei J, Zaika E, Zaika A. p53 family: role of protein isoforms in human cancer. J Nucleic Acids. 2012;2012:687359.

    Article  Google Scholar 

  12. 12.

    Billant O, Léon A, Le Guellec S, Friocourt G, Blondel M, Voisset C. The dominant-negative interplay between p53, p63, p73: a family affair. Oncotarget. 2016;7:69549–64.

    Article  Google Scholar 

  13. 13.

    Yoshikawa H, Nagashima M, Khan MA, McMenamin MG, Hagiwara K, Harris CC. Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene. 1999;18:3415–21.

    CAS  Article  Google Scholar 

  14. 14.

    Mrózek K, Carroll AJ, Maharry K, Rao KW, Patil SR, Pettenati MJ, et al. Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the cancer and leukemia Group B experience. Int J Oncol. 2008;33:239–44.

    PubMed  PubMed Central  Google Scholar 

  15. 15.

    Döhner H, Estey E, Grimwade D, Amadori S, Applebaum FR, Büchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424–47.

    Article  Google Scholar 

Download references


The authors are grateful to the patients who consented to participate in these clinical trials and the families who supported them; to Donna Bucci and the CALGB/Alliance Leukemia Tissue Bank at The Ohio State University Comprehensive Cancer Center, Columbus, OH, for sample processing and storage services and Lisa J. Sterling for data management. This work was supported in part by the National Cancer Institute (grants UG1CA233338 (JCB), CA101140, CA140158, CA180861, CA196171, CA016058, CA180821, CA180882, U24CA196171, R35CA198183 (to JCB) and CA077658), the Leukemia Clinical Research Foundation, the Warren D. Brown Foundation, the Alliance Clinical Scholar program (to ASM), and by an allocation of computing resources from The Ohio Supercomputer Center.

Author information




ASM, JK, A-KE, KM, JCB, and CDB contributed to the study design; ASM, JK, A-KE, KM, JCB, and CDB contributed to the data interpretation, ASM, KM, JK, JCB, and CDB wrote the paper; ASM, A-KE, SO, DP, and DS performed laboratory-based research; JSB performed the data processing; JK and DN performed statistical analysis; RMS, BLP, JEK, KM, JCB, and CDB were involved directly or indirectly in the care of patients and/or sample procurement. All authors read and agreed on the final version of the paper. The authors dedicate this letter to CDB, who died unexpectedly as this paper was being completed. Her mentorship and support fostered all of us to pursue novel approaches to improve outcome for AML patients.

Corresponding author

Correspondence to Alice S. Mims.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mims, A.S., Kohlschmidt, J., Eisfeld, A. et al. Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations. Leukemia (2020).

Download citation