Acute myeloid leukemia

Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations

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Fig. 1: TP73 and TP53 Mutation lollipop plots.
Fig. 2: Kaplan-Meier survival curves.

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Acknowledgements

The authors are grateful to the patients who consented to participate in these clinical trials and the families who supported them; to Donna Bucci and the CALGB/Alliance Leukemia Tissue Bank at The Ohio State University Comprehensive Cancer Center, Columbus, OH, for sample processing and storage services and Lisa J. Sterling for data management. This work was supported in part by the National Cancer Institute (grants UG1CA233338 (JCB), CA101140, CA140158, CA180861, CA196171, CA016058, CA180821, CA180882, U24CA196171, R35CA198183 (to JCB) and CA077658), the Leukemia Clinical Research Foundation, the Warren D. Brown Foundation, the Alliance Clinical Scholar program (to ASM), and by an allocation of computing resources from The Ohio Supercomputer Center.

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ASM, JK, A-KE, KM, JCB, and CDB contributed to the study design; ASM, JK, A-KE, KM, JCB, and CDB contributed to the data interpretation, ASM, KM, JK, JCB, and CDB wrote the paper; ASM, A-KE, SO, DP, and DS performed laboratory-based research; JSB performed the data processing; JK and DN performed statistical analysis; RMS, BLP, JEK, KM, JCB, and CDB were involved directly or indirectly in the care of patients and/or sample procurement. All authors read and agreed on the final version of the paper. The authors dedicate this letter to CDB, who died unexpectedly as this paper was being completed. Her mentorship and support fostered all of us to pursue novel approaches to improve outcome for AML patients.

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Correspondence to Alice S. Mims.

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Mims, A.S., Kohlschmidt, J., Eisfeld, A. et al. Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations. Leukemia (2020). https://doi.org/10.1038/s41375-020-1007-6

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